Evidence map›Paper›PMID 26274972›Full record

ReviewNutrients2015

Diet-Induced Cognitive Deficits: The Role of Fat and Sugar, Potential Mechanisms and Nutritional Interventions.

Jessica E Beilharz, Jayanthi Maniam, Margaret J Morris

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nutrients, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 109 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
109citing papers in PubMed, 4 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

109 citing papers in PubMed, 4 syntheses or guidelines pooled it, 204 citations in OpenAlex.

  1. Pooled it
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  4. Obesity and episodic memory function.The journal of physiological sciences : JPS · 2018
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  7. Neurobehavioral Consequences of Obesity: The Role of Inflammation.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2026
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49 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Jessica E BeilharzDepartment of Pharmacology, School of Medical Sciences, UNSW Australia, UNSW Sydney 2052, Australia. j.beilharz@unsw.edu.au.
Jayanthi ManiamDepartment of Pharmacology, School of Medical Sciences, UNSW Australia, UNSW Sydney 2052, Australia. j.maniam@unsw.edu.au.
Margaret J MorrisDepartment of Pharmacology, School of Medical Sciences, UNSW Australia, UNSW Sydney 2052, Australia. m.morris@unsw.edu.au.
UNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is of vital importance to understand how the foods which are making us fat also act to impair cognition. In this review, we compare the effects of acute and chronic exposure to high-energy diets on cognition and examine the relative contributions of fat (saturated and polyunsaturated) and sugar to these deficits. Hippocampal-dependent memory appears to be particularly vulnerable to the effects of high-energy diets and these deficits can occur rapidly and prior to weight gain. More chronic diet exposure seems necessary however to impair other sorts of memory. Many potential mechanisms have been proposed to underlie diet-induced cognitive decline and we will focus on inflammation and the neurotrophic factor, brain-derived neurotrophic factor (BDNF). Finally, given supplementation of diets with omega-3 and curcumin has been shown to have positive effects on cognitive function in healthy ageing humans and in disease states, we will discuss how these nutritional interventions may attenuate diet-induced cognitive decline. We hope this approach will provide important insights into the causes of diet-induced cognitive deficits, and inform the development of novel therapeutics to prevent or ameliorate such memory impairments.

Indexed as

CognitionBrain-Derived Neurotrophic FactorCarbohydratesCognition DisordersCurcuminDietary SupplementsDiet, High-FatFatty Acids, Omega-3HippocampusHumansMemoryMemory DisordersObesityBDNF protein, humanBrain-Derived Neurotrophic FactorCarbohydratesCurcuminFatty Acids, Omega-3BDNFcurcumindietfathippocampusinflammationinterventionmemoryneurogenesisomega-3sugar

Identifiers

PMID26274972
PMCPMC4555146
OpenAlexW2153315121

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.