ArticlePLoS genetics2015
Strong Selective Sweeps on the X Chromosome in the Human-Chimpanzee Ancestor Explain Its Low Divergence.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 64 citations in OpenAlex.
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- Replicate geographic transects across a hybrid zone reveal parallelism and differences in the genetic architecture of reproductive isolation.Evolution letters · 2025Article
- Patterns of Genomic Heterogeneity in a Classic Field Cricket Mosaic Hybrid Zone.Ecology and evolution · 2024Article
- TRAILS: Tree reconstruction of ancestry using incomplete lineage sorting.PLoS genetics · 2024Article
- Genetic conflict and the origin of multigene families: implications for sex chromosome evolution.Proceedings. Biological sciences · 2023Review
- Extraordinary selection on the human X chromosome associated with archaic admixture.Cell genomics · 2023Article
- The contribution of sex chromosome conflict to disrupted spermatogenesis in hybrid house mice.Genetics · 2022Article
- Genomic architecture constrained placental mammal X Chromosome evolution.Genome research · 2021Article
- Chromosome X-wide Analysis of Positive Selection in Human Populations: Common and Private Signals of Selection and its Impact on Inactivated Genes and Enhancers.Frontiers in genetics · 2021Article
- Female-biased gene flow between two species of Darwin's finches.Nature ecology & evolution · 2020Article
- Population Genomics in the Great Apes.Methods in molecular biology (Clifton, N.J.) · 2020Article
- Article
- Recombination-Aware Phylogenomics Reveals the Structured Genomic Landscape of Hybridizing Cat Species.Molecular biology and evolution · 2019Article
- Haplotypes spanning centromeric regions reveal persistence of large blocks of archaic DNA.eLife · 2019Article
- Exaggerated heterochiasmy in a fish with sex-linked male coloration polymorphisms.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Estimated Pacemaker for Great Apes Supports the Hominoid Slowdown Hypothesis.Evolutionary bioinformatics online · 2019Article
- Genomes reveal marked differences in the adaptive evolution between orangutan species.Genome biology · 2018Article
- Spermatogenesis and the Evolution of Mammalian Sex Chromosomes.Trends in genetics : TIG · 2018Review
- Speciation genes are more likely to have discordant gene trees.Evolution letters · 2018Article
- Dynamic Copy Number Evolution of X- and Y-Linked Ampliconic Genes in Human Populations.Genetics · 2018Article
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5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The human and chimpanzee X chromosomes are less divergent than expected based on autosomal divergence. We study incomplete lineage sorting patterns between humans, chimpanzees and gorillas to show that this low divergence can be entirely explained by megabase-sized regions comprising one-third of the X chromosome, where polymorphism in the human-chimpanzee ancestral species was severely reduced. We show that background selection can explain at most 10% of this reduction of diversity in the ancestor. Instead, we show that several strong selective sweeps in the ancestral species can explain it. We also report evidence of population specific sweeps in extant humans that overlap the regions of low diversity in the ancestral species. These regions further correspond to chromosomal sections shown to be devoid of Neanderthal introgression into modern humans. This suggests that the same X-linked regions that undergo selective sweeps are among the first to form reproductive barriers between diverging species. We hypothesize that meiotic drive is the underlying mechanism causing these two observations.
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