Evidence map›Paper›PMID 26274806›Full record

ArticleAIDS care2016

Menstrual cycle phase and single tablet antiretroviral medication adherence in women with HIV.

Nancy A Hessol, Susan Holman, Howard Minkoff, Mardge H Cohen, Elizabeth T Golub, Seble Kassaye, Roksana Karim, Oluwakemi Sosanya, Christopher Shaheen, Zaher Merhi

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS care, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 9 institutions in 1 country.

Nancy A Hessola Departments of Clinical Pharmacy and of Medicine , University of California , 3333 California Street, Suite 420, San Francisco , CA 94143-0613 , USA.
Susan Holmanb Department of Medicine, College of Medicine and Department of Community Health Sciences, School of Public Health , State University of New York Downstate Medical Center , 450 Clarkson Avenue, Brooklyn , NY , USA.
Howard Minkoffc Department of Obstetrics & Gynecology , Maimonides Medical Center , 967 48th Street, Brooklyn , NY , USA.
Mardge H Cohend CORE Center , Cook County Health and Hospital System , 2225 W. Harrison Street, Chicago , IL , USA.
Elizabeth T Golubf Department of Epidemiology , Bloomberg School of Public Health , Johns Hopkins University, 615 N. Wolfe Street, Baltimore , MD , USA.
Seble Kassayeg Georgetown University School of Medicine , 2115 Wisconsin Avenue, NW, Washington DC , USA.
Roksana Karimh Department of Preventive Medicine , Keck School of Medicine, University of Southern California , 1540 Alcazar, Los Angeles , CA , USA.
Oluwakemi Sosanyai Division of Internal Medicine , Montefiore Medical Center , 3311 Bainbridge Avenue, Bronx , NY , USA.
Christopher Shaheenj Department of Clinical Pharmacy , University of California , 3333 California Street, San Francisco , CA , USA.
Zaher Merhik Department of Obstetrics and Gynecology , New York University School of Medicine , 180 Varick Street, New York , NY , USA.
University of California, San Francisco · USGeorgetown University · USJohns Hopkins University · USMaimonides Medical Center · USMontefiore Medical Center · USNew York University · USRush University · USSUNY Downstate Health Sciences University · USUniversity of Southern California · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Women's Interagency HIV Study (WIHS-V)U01AI035004 · NIAID · MONTEFIORE MEDICAL CENTER (BRONX, NY) · PI ANASTOS, KATHRYN M., SHARMA, ANJALI · 1993 to 2018
$65.7M
WOMEN'S INTERAGENCY HIV STUDY ORGANIZATION, MANAGEMENT AND COMMUNICATIONSU01AI034989 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AOUIZERAT, BRADLEY E, GREENBLATT, RUTH MARTHA · 1993 to 2018
$65.6M
Women's Interagency HIV Study (WIHS) IIIU01AI031834 · NIAID · SUNY DOWNSTATE MEDICAL CENTER · PI GUSTAFSON, DEBORAH R., MINKOFF, HOWARD · 1998 to 2018
$53.5M
WOMEN'S INTERAGENCY HIV STUDY (WIHS) ORGANIZATION AND MANAGEMENTU01AI034994 · NIAID · GEORGETOWN UNIVERSITY · PI KASSAYE, SEBLE G · 1993 to 2018
$52.0M
Women's Interagency HIV Study (WIHS) IV, Chicago ConsortiumU01AI034993 · NIAID · HEKTOEN INSTITUTE FOR MEDICAL RESEARCH · PI COHEN, MARDGE H, FRENCH, AUDREY · 1994 to 2018
$51.0M
WOMENS INTERAGENCY HIV STUDY (WIHS)U01HD032632 · NICHD · UNIVERSITY OF SOUTHERN CALIFORNIA · PI MILAM, JOEL E · 1994 to 2012
$42.0M
WIHS DATA MANAGEMENT AND ANALYSIS CENTER(WDMAC)U01AI042590 · NIAID · JOHNS HOPKINS UNIVERSITY · PI GANGE, STEPHEN J, GOLUB, ELIZABETH T · 1998 to 2018
$38.4M
NCRR NIH HHS UL1 RR024131NIAID NIH HHS U01 AI031834NIAID NIH HHS U01 AI034989NIAID NIH HHS U01 AI034993NIAID NIH HHS U01 AI034994NIAID NIH HHS U01 AI035004NIAID NIH HHS U01 AI042590NIAID NIH HHS U01-AI-42590NIAID NIH HHS UO1-AI-31834NIAID NIH HHS UO1-AI-34989NIAID NIH HHS UO1-AI-34993NIAID NIH HHS UO1-AI-34994NIAID NIH HHS UO1-AI-35004NICHD NIH HHS U01 HD032632NICHD NIH HHS UO1-HD-32632
6 · The paper itself

Abstract

Suboptimal adherence to antiretroviral (ARV) therapy among HIV-infected individuals is associated with increased risk of progression to AIDS and the development of HIV resistance to ARV medications. To examine whether the luteal phase of the menstrual cycle is independently associated with suboptimal adherence to single tablet regimen (STR) ARV medication, data were analyzed from a multicenter cohort study of HIV-infected women who reported regular menstrual cycles and were taking an STR. In a cross-sectional analysis, suboptimal adherence to an STR among women in their follicular phase was compared with suboptimal adherence among women in their luteal phase. In two-way crossover analyses, whereby the same woman was assessed for STR medication adherence in both her follicular and luteal phases, the estimated exact conditional odds of non-adherence to an STR was measured. In adjusted logistic regression analysis of the cross-sectional data (N=327), women with ≤12 years of education were more than three times more likely to have suboptimal adherence (OR=3.6, p=.04) compared to those with >12 years of education. Additionally, women with Center for Epidemiological Studies Depression Scale (CES-D) scores ≥23 were 2.5-times more likely to have suboptimal adherence (OR=2.6, p=.02) compared to those with CES-D scores <23. In conditional logistic regression analyses of the crossover data (N=184), having childcare responsibilities was associated with greater odds of ≤95% adherence. Menstrual cycle phase was not associated with STR adherence in either the cross-sectional or crossover analyses. The lack of association between phase of the menstrual cycle and adherence to an STR in HIV-infected women means attention can be given to other more important risk factors for suboptimal adherence, such as depression, level of education, and childcare responsibilities.

Indexed as

Medication AdherenceAdultAnti-Retroviral AgentsCross-Over StudiesCross-Sectional StudiesFemaleFollicular PhaseHIV InfectionsHumansLuteal PhaseMiddle AgedRegression AnalysisSocioeconomic FactorsTabletsYoung AdultAnti-Retroviral AgentsTabletsHIVmedication adherencemenstrual phasewomen

Identifiers

PMID26274806
PMCPMC4713239
OpenAlexW1507003444

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.