SynthesisAnnals of the Royal College of Surgeons of England2015
Meta-analysis of elective surgical complications related to defunctioning loop ileostomy compared with loop colostomy after low anterior resection for rectal carcinoma.
Synthesis in Annals of the Royal College of Surgeons of England, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 6 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 6 syntheses or guidelines pooled it, 57 citations in OpenAlex.
- Risk and protective factors for postoperative anastomotic leakage in esophageal and gastrointestinal surgery: an umbrella review of meta-analyses and systematic reviews.International journal of surgery (London, England) · 2026Pooled it
- Complications of preventive loop ileostomy versus colostomy: a meta-analysis, trial sequential analysis, and systematic review.BMC surgery · 2023Pooled it
- A meta-analysis of the role of diverting ileostomy after rectal cancer surgery.International journal of colorectal disease · 2021Pooled it
- Italian guidelines for the surgical management of enteral stomas in adults.Techniques in coloproctology · 2019Guideline
- Prophylactic mesh placement to avoid incisional hernias after stoma reversal: a systematic review and meta-analysis.Hernia : the journal of hernias and abdominal wall surgery · 2019Pooled it
- The influence of diverting loop ileostomy vs. colostomy on postoperative morbidity in restorative anterior resection for rectal cancer: a systematic review and meta-analysis.Langenbeck's archives of surgery · 2019Pooled it
- Analysis of diverting ileostomy for colorectal cancer surgery: stenosis and T4 invasion are risk factors of reoperation due to anastomotic leakage, even when ileostomy is performed.International journal of colorectal disease · 2026Article
- Article
- The impact of Low-Anterior Resection Syndrome (LARS) on the Quality of Life in Rectal Cancer Survivors: a Narrative Review.Maedica · 2025Review
- Risk factors for complications after infantile enterostomy: development of a clinical prediction model.Frontiers in public health · 2025Article
- Review
- Feasibility and outcomes of robotic sphincter-preserving surgery for rectal cancer after neoadjuvant treatment in patients with preexisting colostomy.Techniques in coloproctology · 2024Article
- The Role of Colon in Isolated Intestinal Transplantation: Description of 4 Cases.International journal of surgical oncology · 2024Article
- Temporary loop ileostomy versus transverse colostomy for laparoscopic colorectal surgery: a retrospective study.Surgery today · 2023Article
- Essential updates 2020/2021: Advancing precision medicine for comprehensive rectal cancer treatment.Annals of gastroenterological surgery · 2023Review
- An empirical comparison of the harmful effects for randomized controlled trials and non-randomized studies of interventions.Frontiers in pharmacology · 2023Article
- Cost-effectiveness of Total Neoadjuvant Therapy With Short-Course Radiotherapy for Resectable Locally Advanced Rectal Cancer.JAMA network open · 2022Article
- Risk Factors for Anastomotic Leak, Consideration for Proximal Diversion, and Appropriate Use of Drains.Clinics in colon and rectal surgery · 2021Review
- One-stitch method vs. traditional method of protective loop ileostomy for rectal cancer: the impact of BMI obesity.Journal of cancer research and clinical oncology · 2021Article
- Comparison of the clinical outcomes of skin bridge loop ileostomy and traditional loop ileostomy in patients with low rectal cancer.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction Defunctioning loop ileostomy (LI) and loop colostomy (LC) are used widely to protect/treat anastomotic leakage after colorectal surgery. However, it is not known which surgical approach has a lower prevalence of surgical complications after low anterior resection for rectal carcinoma (LARRC). Methods We conducted a literature search of PubMed, MEDLINE, Ovid, Embase and Cochrane databases to identify studies published between 1966 and 2013 focusing on elective surgical complications related to defunctioning LI and LC undertaken to protect a distal rectal anastomosis after LARRC. Results Five studies (two randomized controlled trials, one prospective non-randomized trial, and two retrospective trials) satisfied the inclusion criteria. Outcomes of 1,025 patients (652 LI and 373 LC) were analyzed. After the construction of a LI or LC, there was a significantly lower prevalence of sepsis (p=0.04), prolapse (p=0.03), and parastomal hernia (p=0.02) in LI patients than in LC patients. Also, the prevalence of overall complications was significantly lower in those who received LIs compared with those who received LCs (p<0.0001). After closure of defunctioning loops, there were significantly fewer wound infections (p=0.006) and incisional hernias (p=0.007) in LI patients than in LC patients, but there was no significant difference between the two groups in terms of overall complications. Conclusions The results of this meta-analysis show that a defunctioning LI may be superior to LC with respect to a lower prevalence of surgical complications after LARRC.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.