Evidence map›Paper›PMID 26274611›Full record

ReviewRNA biology2015

The molecular mechanism of translational control via the communication between the microRNA pathway and RNA-binding proteins.

Akira Fukao, Tomohiko Aoyama, Toshinobu Fujiwara

Abstract readReview
In one paragraph

Review in RNA biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Stress-Induced Eukaryotic Translational Regulatory Mechanisms.Journal of clinical and medical sciences · 2024
    Article
  5. Integrative Analysis ofGlobal medical genetics · 2023
    Article
  6. Article
  7. Article
  8. Review
  9. Modulation of miRISC-Mediated Gene Silencing in Eukaryotes.Frontiers in molecular biosciences · 2022
    Review
  10. Review
  11. Article
  12. Article
  13. The Role of Dynamic miRISC During Neuronal Development.Frontiers in molecular biosciences · 2020
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Akira Fukaoa Laboratory of Biochemistry; Department of Pharmacy; Kinki University ; Higashi-Osaka , Japan.
Tomohiko Aoyamab Graduate School of Pharmaceutical Sciences; Nagoya City University ; Mizuho-ku, Nagoya , Japan.
Toshinobu Fujiwaraa Laboratory of Biochemistry; Department of Pharmacy; Kinki University ; Higashi-Osaka , Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs found in most plants and animals. The miRNA pathway regulates posttranscriptional gene expression through the deadenylation and translation repression of target mRNAs. Recent studies revealed that the early step of translation initiation is the target of "pure" translation repression by the miRNA pathway. Moreover, particularly in animals, the miRNA pathway is required for neuronal development, differentiation, and plasticity. In addition, some functions of miRNAs are regulated by RNA-binding proteins (RBPs) in neuronal cells. This review summarizes new insights about the molecular mechanisms of pure translation repression by miRNA pathway and the communication between the miRNA pathway and RBPs in neuronal local translation.

Indexed as

Gene Expression RegulationProtein BiosynthesisAnimalsDown-RegulationGene SilencingHeterogeneous-Nuclear Ribonucleoprotein DHumansMicroRNAsNeuronsRNA-Binding ProteinsRNA-Induced Silencing ComplexRNA, MessengerHeterogeneous-Nuclear Ribonucleoprotein DMicroRNAsRNA-Binding ProteinsRNA-Induced Silencing ComplexRNA, Messengerdeadenylationlocal translationmicroRNApure translationRNA-binding protein

Identifiers

PMID26274611
PMCPMC4615170

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.