ArticlePLoS genetics2015
Cyclin G Functions as a Positive Regulator of Growth and Metabolism in Drosophila.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 22 citations in OpenAlex.
- Genetic and Molecular Interactions betweenGenes · 2023Article
- A single-cell transcriptomic atlas characterizes the silk-producing organ in the silkworm.Nature communications · 2022Article
- Genome annotation with long RNA reads reveals new patterns of gene expression and improves single-cell analyses in an ant brain.BMC biology · 2021Article
- The Membrane-Bound Notch Regulator Mnr Supports Notch Cleavage and Signaling Activity inBiomolecules · 2021Article
- Protein Kinase D Is Dispensable for Development and Survival ofG3 (Bethesda, Md.) · 2019Article
- STRIPAK Members Orchestrate Hippo and Insulin Receptor Signaling to Promote Neural Stem Cell Reactivation.Cell reports · 2019Article
- Systemic signalling and local effectors in developmental stability, body symmetry, and size.Cell stress · 2018Review
- Cyclin G and the Polycomb Repressive complexes PRC1 and PR-DUB cooperate for developmental stability.PLoS genetics · 2018Article
- p53 and cyclin G cooperate in mediating genome stability in somatic cells of Drosophila.Scientific reports · 2017Article
- In vivo analysis of internal ribosome entry at the Hairless locus by genome engineering in Drosophila.Scientific reports · 2016Article
- Article
- Drosophila Cyclin G Is a Regulator of the Notch Signalling Pathway during Wing Development.PloS one · 2016Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In multicellular organisms, growth and proliferation is adjusted to nutritional conditions by a complex signaling network. The Insulin receptor/target of rapamycin (InR/TOR) signaling cascade plays a pivotal role in nutrient dependent growth regulation in Drosophila and mammals alike. Here we identify Cyclin G (CycG) as a regulator of growth and metabolism in Drosophila. CycG mutants have a reduced body size and weight and show signs of starvation accompanied by a disturbed fat metabolism. InR/TOR signaling activity is impaired in cycG mutants, combined with a reduced phosphorylation status of the kinase Akt1 and the downstream factors S6-kinase and eukaryotic translation initiation factor 4E binding protein (4E-BP). Moreover, the expression and accumulation of Drosophila insulin like peptides (dILPs) is disturbed in cycG mutant brains. Using a reporter assay, we show that the activity of one of the first effectors of InR signaling, Phosphoinositide 3-kinase (PI3K92E), is unaffected in cycG mutants. However, the metabolic defects and weight loss in cycG mutants were rescued by overexpression of Akt1 specifically in the fat body and by mutants in widerborst (wdb), the B'-subunit of the phosphatase PP2A, known to downregulate Akt1 by dephosphorylation. Together, our data suggest that CycG acts at the level of Akt1 to regulate growth and metabolism via PP2A in Drosophila.
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