ArticleInternational journal of circumpolar health2015
Fatty acids linked to cardiovascular mortality are associated with risk factors.
Article in International journal of circumpolar health, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 61 citations in OpenAlex.
- Saturated Fatty Acid Chain Length and Risk of Cardiovascular Disease: A Systematic Review.Nutrients · 2022Pooled it
- Risk Factors Associated with Cardiac Autonomic Modulation in Obese Individuals.Journal of obesity · 2020Trial
- Effects of Prepartum Supplementation with Flaxseed and Black Soldier Fly Larvae Oils on Fatty Acid Composition and Lipid Quality Indices in Sheep Milk.Molecules (Basel, Switzerland) · 2026Article
- A long-term mild high-fat diet facilitates rabbit discrimination learning and alters glycerophospholipid metabolism.Neurobiology of learning and memory · 2025Article
- Saturated fat replacement in short dough biscuits with HPMC and lecithin stabilised nanoemulsions.NPJ science of food · 2023Article
- Article
- Direct cardio-protection of Dapagliflozin against obesity-related cardiomyopathy via NHE1/MAPK signaling.Acta pharmacologica Sinica · 2022Article
- Development of Saturated Fat Replacers: Conventional and Nano-Emulsions Stabilised by Lecithin and Hydroxylpropyl Methylcellulose.Foods (Basel, Switzerland) · 2022Article
- EFFICACY OF A LIPID-LOWERING DIET ON KEY FATTY ACID RATIOS AND OMEGA-3 INDEX IN HYPERLIPIDEMIC SUBJECTS.Acta clinica Croatica · 2022Article
- Red blood cell fatty acid patterns from 7 countries: Focus on the Omega-3 index.Prostaglandins, leukotrienes, and essential fatty acids · 2022Article
- Physical and Chemical Characterisation of Conventional and Nano/Emulsions: Influence of Vegetable Oils from Different Origins.Foods (Basel, Switzerland) · 2022Article
- Protective Effects of Naringenin fromNutrients · 2022Article
- Review
- Myristic Acid Serum Levels and Their Significance for Diagnosis of Systemic Inflammatory Response, Sepsis, and Bacteraemia.Journal of personalized medicine · 2021Article
- Egg and Dietary Cholesterol Consumption and Mortality Among Hypertensive Patients: Results From a Population-Based Nationwide Study.Frontiers in nutrition · 2021Article
- Comparative Analysis of Milk Triglycerides Profile between Jaffarabadi Buffalo and Holstein Friesian Cow.Metabolites · 2020Article
- Cannabinoid Receptor Agonist WIN55, 212-2 Adjusts Lipid Metabolism in a Rat Model of Cardiac Arrest.Therapeutic hypothermia and temperature management · 2020Article
- Relationships of Fatty Acids, Delta-5 Desaturase Activity, and Lipid Profiles in Men with Acute Coronary Syndrome.Journal of atherosclerosis and thrombosis · 2020Article
- The Short Overview on the Relevance of Fatty Acids for Human Cardiovascular Disorders.Biomolecules · 2020Review
- Plasma and urine metabolomic analyses in aortic valve stenosis reveal shared and biofluid-specific changes in metabolite levels.PloS one · 2020Article
Corrections and comments
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Authors and funding
16 authors at 11 institutions in 3 countries.
Funding
Abstract
backgroundAlthough saturated fatty acids (FAs) have been linked to cardiovascular mortality, it is not clear whether this outcome is attributable solely to their effects on low-density lipoprotein cholesterol (LDL-C) or whether other risk factors are also associated with FAs. The Western Alaskan Native population, with its rapidly changing lifestyles, shift in diet from unsaturated to saturated fatty acids and dramatic increase in cardiovascular disease (CVD), presents an opportunity to elucidate any associations between specific FAs and known CVD risk factors.
objectiveWe tested the hypothesis that the specific FAs previously identified as related to CVD mortality are also associated with individual CVD risk factors.
methodsIn this community-based, cross-sectional study, relative proportions of FAs in plasma and red blood cell membranes were compared with CVD risk factors in a sample of 758 men and women aged ≥35 years. Linear regression analyses were used to analyze relations between specific FAs and CVD risk factors (LDL-C, high-density lipoprotein cholesterol, triglycerides, C-reactive protein, systolic blood pressure, diastolic blood pressure, heart rate, body mass index, fasting glucose and fasting insulin, 2-hour glucose and 2-hour insulin).
resultsThe specific saturated FAs previously identified as related to CVD mortality, the palmitic and myristic acids, were adversely associated with most CVD risk factors, whereas unsaturated linoleic acid (18:2n-6) and the marine n-3 FAs were not associated or were beneficially associated with CVD risk factors.
conclusionsThe results suggest that CVD risk factors are more extensively affected by individual FAs than hitherto recognized, and that risk for CVD, MI and stroke can be reduced by reducing the intake of palmitate, myristic acid and simple carbohydrates and improved by greater intake of linoleic acid and marine n-3 FAs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.