Evidence map›Paper›PMID 26274015›Full record

ArticleArthritis care & research2015

Differential Association of Psychosocial Comorbidities With Subclinical Atherosclerosis in Rheumatoid Arthritis.

Ying L Liu, Moyses Szklo, Karina W Davidson, Joan M Bathon, Jon T Giles

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis care & research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 3 pooled it
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 3 syntheses or guidelines pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Ying L LiuCollege of Physicians and Surgeons, Columbia University, New York, New York.
Moyses SzkloJohns Hopkins School of Public Health, Baltimore, Maryland.
Karina W DavidsonCollege of Physicians and Surgeons, Columbia University, New York, New York.
Joan M BathonCollege of Physicians and Surgeons, Columbia University, New York, New York.
Jon T GilesCollege of Physicians and Surgeons, Columbia University, New York, New York.
Columbia University · USJohns Hopkins University · US

Funding

Inflammation and Cardiovascular Disease in Rheumatoid ArthritisR01AR050026 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BATHON, JOAN MARIE · 2004 to 2022
$9.7M
Inflammation and Cardiovascular Disease in RAR55AR050026 · NIAMS · JOHNS HOPKINS UNIVERSITY · PI BATHON, JOAN MARIE · 2003 to 2003
$100k
NIAMS NIH HHS AR050026-01NIAMS NIH HHS R01 AR050026NIAMS NIH HHS R55 AR050026
6 · The paper itself

Abstract

objectiveRheumatoid arthritis (RA) is associated with an elevated risk of cardiovascular disease (CVD) events and subclinical atherosclerosis, but the reasons for the excess risk are unclear. We explored whether psychosocial comorbidities, which may be associated with CVD in the general population, are differentially associated with subclinical atherosclerosis in RA compared to controls.

methodsData were from a longitudinal cohort study of 195 RA patients and 1,073 non-RA controls. Using validated scales, heterogeneity in the associations of psychosocial measures (depression, stress, anxiety/anger, support, discrimination/hassles) with measures of subclinical atherosclerosis (coronary artery calcium [CAC] and carotid intima-media thickness [IMT]/plaque) were compared in RA and non-RA groups using multivariable generalized linear models. Computed tomography and ultrasound were used to identify CAC and IMT/plaque, respectively. CAC >100 units was used to define moderate/severe CAC.

resultsIn RA, per-unit higher anxiety scores (odds ratio [OR] 1.10, P = 0.029), anger scores (OR 1.14, P = 0.037), depressive symptoms (OR 3.41, P = 0.032), and caregiver stress (OR 2.86, P = 0.014) were associated with increased odds of CAC >100 units after adjustment for relevant covariates. These findings persisted despite adjustment for markers of inflammation (C-reactive protein and interleukin-6 levels) and were seen only in RA, not in controls (adjusted multiplicative interaction P = 0.001-0.077). In RA, job stress was associated with an increased risk of carotid plaque (adjusted OR = 3.21, P = 0.019), and increasing social support was associated with lower internal carotid IMT (adjusted P = 0.024).

conclusionDepressive symptoms, stress, anger/anxiety, and social support may preferentially affect CVD risk in RA, and screening/treatment for psychosocial morbidities in RA may help ameliorate the additional CVD burden.

Indexed as

AgedAged, 80 and overAge DistributionAnxietyArthritis, RheumatoidAtherosclerosisCardiovascular DiseasesCase-Control StudiesComorbidityCoronary Artery DiseaseDepressive DisorderFemaleHumansLinear ModelsLogistic ModelsLongitudinal Studies

Identifiers

PMID26274015
PMCPMC6058701
OpenAlexW1899353503

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.