Evidence map›Paper›PMID 26273993›Full record

ArticleThe Journal of organic chemistry2015

Application of 3D NMR for Structure Determination of Peptide Natural Products.

Fan Zhang, Navid Adnani, Emmanuel Vazquez-Rivera, Doug R Braun, Marco Tonelli, David R Andes, Tim S Bugni

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Fan ZhangPharmaceutical Sciences Division, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Navid AdnaniPharmaceutical Sciences Division, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Emmanuel Vazquez-RiveraMolecular & Environmental Toxicology Center, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Doug R BraunPharmaceutical Sciences Division, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Marco TonelliNational Magnetic Resonance Facility at Madison, University of Wisconsin-Madison , Madison, Wisconsin 53706, United States.
David R AndesDepartment of Medicine, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.
Tim S BugniPharmaceutical Sciences Division, University of Wisconsin-Madison , Madison, Wisconsin 53705, United States.

Funding

Metabolomics driven discovery of drug leads from symbiotic bacteriaU19AI109673 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI CLARDY, JON, CURRIE, CAMERON ROBERT · 2014 to 2018
$16.2M
WATER DISTRIB:PHYSICAL PROPERT:PIZZA &LMPS MOZZARELLA CHEESES:EARLY STAGE MATURP41RR002301 · NCRR · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 1985 to 2011
$13.0M
TR&D 3: TECHNOLOGY DEVELOPMENT FOR NMR STUDIES OF SMALL MOLECULES (METABOLOMICS, NATURAL PRODUCTS, METABOLITE-PROTEIN INTERACTIONS) pp.537-585 P41GM103399 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN LUTE · 2012 to 2019
$9.4M
900 MHz NMR Spectrometer Biomolecular InvestigationsP41GM066326 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI MARKLEY, JOHN L · 2002 to 2006
$5.0M
Marine symbiotic interactions for discovery of bioactive compoundsR01GM107557 · NIGMS · UNIVERSITY OF UTAH · PI SCHMIDT, ERIC W · 2013 to 2016
$1.2M
NCRR NIH HHS P41 RR002301NCRR NIH HHS P41RR02301NIAID NIH HHS U19 AI109673NIGMS NIH HHS P41 GM066326NIGMS NIH HHS P41 GM103399NIGMS NIH HHS P41GM66326NIGMS NIH HHS R01 GM107557
6 · The paper itself

Abstract

Despite the advances in NMR, structure determination is often slow and constitutes a bottleneck in natural products discovery. Removal of this bottleneck would greatly improve the throughput for antibiotic discovery as well as other therapeutic areas. Overall, faster structure methods for structure determination will serve the natural products community in a broad manner. This report describes the first application of 3D NMR for elucidation of two microbially produced peptide natural products with novel structures. The methods are cost-effective and greatly improve the confidence in a proposed structure.

Indexed as

Biological ProductsMagnetic Resonance SpectroscopyMolecular ConformationMolecular StructurePeptidesBiological ProductsPeptides

Identifiers

PMID26273993
PMCPMC4696765

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.