ArticlePLoS computational biology2015
The Role of Cell Volume in the Dynamics of Seizure, Spreading Depression, and Anoxic Depolarization.
Article in PLoS computational biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 93 citations in OpenAlex.
- Tsunamis hiding in plain sight: spreading depression in clinical neurology.Nature reviews. Neurology · 2026Review
- Data driven multiscale modelling of paroxysmal brain transitions using DC-coupled electrophysiological data.PloS one · 2026Article
- Deep Learning-Based Prediction of Individual CellBiosensors · 2025Article
- An Empirical-Theoretical Approach to Determine Astroglial Potassium Upon Ischemic Stress.Methods in molecular biology (Clifton, N.J.) · 2025Article
- The impact of dynamic reversal potential on the evolution of action potential attributes during spike trains.Frontiers in computational neuroscience · 2025Article
- Deep-Learning-Based Segmentation of Cells and Analysis (DL-SCAN).Biomolecules · 2024Article
- Mathematical modeling of intracellular osmolarity and cell volume stabilization: The Donnan effect and ion transport.The Journal of general physiology · 2024Article
- Indirect Effects of Halorhodopsin Activation: Potassium Redistribution, Nonspecific Inhibition, and Spreading Depolarization.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Slow ion concentration oscillations and multiple states in neuron-glia interaction-insights gained from reduced mathematical models.Frontiers in network physiology · 2023Article
- Interneuronal dynamics facilitate the initiation of spike block in cortical microcircuits.Journal of computational neuroscience · 2022Article
- Pregabalin for Recurrent Seizures in Critical Illness: A Promising Adjunctive Therapy, Especially for cyclic Seizures.Neurocritical care · 2022Article
- Changes in Astroglial KInternational journal of molecular sciences · 2022Article
- Action Potentials Are Critical for the Propagation of Focally Elicited Spreading Depolarizations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Classification of bursting patterns: A tale of two ducks.PLoS computational biology · 2022Review
- New inroads into the brain circuits and network dynamics behind sudden unexpected death in epilepsy.Brain communications · 2022Article
- Impact of DC-Coupled Electrophysiological Recordings for Translational Neuroscience: Case Study of Tracking Neural Dynamics in Rodent Models of Seizures.Frontiers in computational neuroscience · 2022Article
- Canard solutions in neural mass models: consequences on critical regimes.Journal of mathematical neuroscience · 2021Article
- A tridomain model for potassium clearance in optic nerve of Necturus.Biophysical journal · 2021Article
- Is Spreading Depolarization a Risk Factor for Late Epilepsy? A Prospective Study in Patients with Traumatic Brain Injury and Malignant Ischemic Stroke Undergoing Decompressive Craniectomy.Neurocritical care · 2021Observational
- Ion dynamics at the energy-deprived tripartite synapse.PLoS computational biology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 5 institutions in 3 countries.
Funding
Abstract
Cell volume changes are ubiquitous in normal and pathological activity of the brain. Nevertheless, we know little of how cell volume affects neuronal dynamics. We here performed the first detailed study of the effects of cell volume on neuronal dynamics. By incorporating cell swelling together with dynamic ion concentrations and oxygen supply into Hodgkin-Huxley type spiking dynamics, we demonstrate the spontaneous transition between epileptic seizure and spreading depression states as the cell swells and contracts in response to changes in osmotic pressure. Our use of volume as an order parameter further revealed a dynamical definition for the experimentally described physiological ceiling that separates seizure from spreading depression, as well as predicted a second ceiling that demarcates spreading depression from anoxic depolarization. Our model highlights the neuroprotective role of glial K buffering against seizures and spreading depression, and provides novel insights into anoxic depolarization and the relevant cell swelling during ischemia. We argue that the dynamics of seizures, spreading depression, and anoxic depolarization lie along a continuum of the repertoire of the neuron membrane that can be understood only when the dynamic ion concentrations, oxygen homeostasis,and cell swelling in response to osmotic pressure are taken into consideration. Our results demonstrate the feasibility of a unified framework for a wide range of neuronal behaviors that may be of substantial importance in the understanding of and potentially developing universal intervention strategies for these pathological states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.