Evidence map›Paper›PMID 26273660›Full record

ArticleBioMed research international2015

Analysis of Erythrocyte C4d to Complement Receptor 1 Ratio: Use in Distinguishing between Infection and Flare-Up in Febrile Patients with Systemic Lupus Erythematosus.

Chen-Hung Chen, Shun-Ban Tai, Hsiang-Cheng Chen, Deng-Ho Yang, Ming-Yieh Peng, Yuh-Feng Lin

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Vaccine-preventable infections in Systemic Lupus Erythematosus.Human vaccines & immunotherapeutics · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Chen-Hung ChenGraduate Institute of Clinical Medicine, Taipei Medical University, Taipei 11031, Taiwan ; Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu Chi University, Hualien 970, Taiwan ; Division of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Shun-Ban TaiDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Armed-Forces Zuoying General Hospital, Kaohsiung 81342, Taiwan.
Hsiang-Cheng ChenDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 11490, Taiwan.
Deng-Ho YangDivision of Rheumatology, Immunology and Allergy, Department of Internal Medicine, Armed-Forces Taichung General Hospital, Taichung 41168, Taiwan.
Ming-Yieh PengDivision of Infection, Department of Internal Medicine, Taipei Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, School of Medicine, Tzu Chi University, Hualien 970, Taiwan.
Yuh-Feng LinGraduate Institute of Clinical Medicine, Taipei Medical University, Taipei 11031, Taiwan ; Division of Nephrology, Department of Medicine, Shuang Ho Hospital, Taipei Medical University, New Taipei 23561, Taiwan.
National Defense Medical Center · TWTaichung Armed Forces General Hospital · TWTaipei Medical University-Shuang Ho Hospital · TWTaipei Tzu Chi Hospital · TWTzu Chi University · TWZuoying Armed Forces General Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveFever in systemic lupus erythematosus (SLE) can be caused by infection or flare-up of the disease. This study aimed to determine whether the ratio of the level of erythrocyte-bound C4d to that of complement receptor 1 (C4d/CR1) can serve as a useful biomarker in the differentiation between infection and flare-up in febrile SLE patients.

methodsWe enrolled febrile SLE patients and determined the ratio on the day of admission. The patients were divided into 2 groups according to the subsequent clinical course.

resultsAmong the febrile SLE patients, those with flare-up had higher ratios and lower C-reactive protein (CRP) levels than those with infection. Cut-off values of <1.2447 and >4.67 for C4d/CR1 ratio and CRP, respectively, were 40.91% sensitive and 100.0% specific for the presence of infection in febrile SLE patients; similarly, cut-off values of >1.2447 and <2.2, respectively, were 80% sensitive and 100% specific for the absence of infection in febrile SLE patients.

conclusionThe C4d/CR1 ratio is a simple and quickly determinable biomarker that enables the differentiation between infection and flare-up in febrile SLE patients at initial evaluation. Further, when combined with the CRP level, it is useful to evaluate disease activity in SLE patients with infection.

Indexed as

AdolescentAdultAgedAged, 80 and overBiomarkersComplement C4bDiagnosis, DifferentialErythrocytesFemaleFeverHumansInfectionsLupus Erythematosus, SystemicMaleMiddle AgedPeptide FragmentsBiomarkersComplement C4bcomplement C4dPeptide FragmentsReceptors, Complement

Identifiers

PMID26273660
PMCPMC4529962
OpenAlexW1492791826

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.