Evidence map›Paper›PMID 26273655›Full record

ArticleBioMed research international2015

MUTYH Gene Polymorphisms as Risk Factors for Rheumatoid Arthritis.

Yung-Jen Kung, Kun Shi Tsai, Chung-Ming Huang, Hui-Ju Lin, Ter-Hsin Chen, Yu-An Hsu, Ching-Yao Chang, Yong-San Huang, Lei Wan

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. MUTYH: Not just polyposis.World journal of clinical oncology · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Yung-Jen KungDepartment of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
Kun Shi TsaiDepartment of Biological Science and Technology, National Chiao Tung University, Hsinchu 30010, Taiwan.
Chung-Ming HuangGraduate Institute of Integrated Medicine, China Medical University, Taichung 40402, Taiwan ; Division of Immunology and Rheumatology, Department of Internal Medicine, China Medical University Hospital, Taichung 40402, Taiwan.
Hui-Ju LinDepartment of Ophthalmology, China Medical University Hospital, Taichung 40402, Taiwan.
Ter-Hsin ChenGraduate Institute of Veterinary Pathobiology, National Chung Hsing University, Taichung 40227, Taiwan.
Yu-An HsuDepartment of Life Science, National Tsing Hua University, Hsinchu 30013, Taiwan.
Ching-Yao ChangDepartment of Medical Research, China Medical University Hospital, Taichung 40402, Taiwan ; Department of Biotechnology, Asia University, Taichung 41354, Taiwan.
Yong-San HuangDepartment of Veterinary Medicine, National Chung Hsing University, Taichung 40227, Taiwan.
Lei WanDepartment of Biotechnology, Asia University, Taichung 41354, Taiwan ; School of Chinese Medicine, China Medical University, No. 91, Hsueh-Shih Road, Taichung 40402, Taiwan ; Department of Gynecology, China Medical University Hospital, Taichung 40402, Taiwan.
National Chung Hsing University · TWChina Medical University · TWChina Medical University Hospital · TWNational Tsing Hua University · TWNational Yang Ming Chiao Tung University · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesMUTYH glycosylase involved in DNA repair pathways may be associated with the risk of autoimmune diseases such as rheumatoid arthritis (RA). Therefore, the association between polymorphisms in the MUTYH gene and RA was evaluated.

methodsWe recruited 192 RA patients and 192 healthy subjects in Taiwan. The 4 MUTYH polymorphisms (rs3219463, rs3219476, rs3219489, and rs3219493) were detected and haplotype analysis was performed using the Bayesian method. The genotype and allelic frequency distributions of the polymorphisms in both RA patients and healthy patients were compared by the chi-square test.

resultsComparison of the genotype/allele frequencies between individuals with RA and the control groups revealed significant differences in 2 MUTYH gene polymorphisms, rs3219463 and rs3219476. After we performed a haplotype-specific analysis, the haplotypes Ht6-GTGC and Ht8-GGCG had lower presenting rates in RA patients than in the control groups. Furthermore, the genotype frequency of rs3219463 G/  was significantly increased among patients with immunoglobulin M rheumatoid factors, whereas that of rs3219476 was not.

conclusionWe demonstrated that the rs3219463 and rs3219476 polymorphisms in RA patients from a Taiwan Chinese population were associated with disease susceptibility. These data indicate that the MUTYH gene may play a role in the progression of RA.

Indexed as

Arthritis, RheumatoidBase SequenceDNA GlycosylasesFemaleGenetic MarkersGenetic Predisposition to DiseaseHaplotypesHumansIncidenceMaleMiddle AgedMolecular Sequence DataPolymorphism, Single NucleotideReproducibility of ResultsRisk FactorsSensitivity and SpecificityDNA GlycosylasesGenetic MarkersmutY adenine glycosylase

Identifiers

PMID26273655
PMCPMC4530216
OpenAlexW1539898183

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.