ArticleBioMed research international2015
Clinical Features in Juvenile-Onset Ankylosing Spondylitis Patients Carrying Different B27 Subtypes.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 30 citations in OpenAlex.
- From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis.Arthritis care & research · 2026Review
- Juvenile Spondyloarthropathies: Diagnostic and Therapeutic Advances-A Narrative Review.Journal of clinical medicine · 2025Review
- Spectrum of Spondyloarthritis Among Chinese Populations.Current rheumatology reports · 2022Review
- Associations between HLA-B27 subtypes and outcomes in Thai children with enthesitis-related arthritis.Clinical rheumatology · 2022Article
- Spondyloarthritis in North Africa: an update.Clinical rheumatology · 2021Review
- HLA-subtypes B*27 and ankylosing spondylitis features comments on Fellahi's article "Are early onset of disease and uveitis affected by HLA- subtypes B*27 in ankylosing spondylitis?"Clinical rheumatology · 2021Article
- Are the earlier disease onset and uveitis affected by the HLA-B*27 subtypes in ankylosing spondylitis? Comments on the article by Silmani et al.Clinical rheumatology · 2021Article
- An unusual presentation of ankylosing spondylitis.Singapore medical journal · 2020Article
- Enthesitis-related arthritis is the most common category of juvenile idiopathic arthritis in Taiwan and presents persistent active disease.Pediatric rheumatology online journal · 2019Observational
- Optimization of an in-house PCR method for the detection of HLA-B*27 alleles.Biomedical reports · 2018Article
- Polymorphisms of human leukocyte antigen B*27 on clinical phenotype of spondyloarthritis in Chinese.Journal of clinical laboratory analysis · 2018Article
- Does HLA-B27 Status Influence Ankylosing Spondylitis Phenotype?Clinical medicine insights. Arthritis and musculoskeletal disorders · 2018Review
- Association of HLA‑B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al.Rheumatology international · 2017Article
- Reply to "Association of HLA-B27 and its subtypes with ankylosing spondylitis and clinical manifestations of ankylosing spondylitis in different HLA-B27 subtypes: comment on the article by Lin et al."Rheumatology international · 2017Article
- An Update on the Genetic Polymorphism of HLA-B*27 With 213 Alleles Encompassing 160 Subtypes (and Still Counting).Current rheumatology reports · 2017Review
- A meta-analysis for association of TNF-α -308G>A polymorphism with susceptibility to Ankylosing Spondylitis.Journal of orthopaedicsReview
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAnkylosing spondylitis (AS) is a common rheumatic disease and is characterized by inflammation of the axial skeleton. HLA-B27 is strongly associated with AS. Juvenile-onset AS (JAS) with disease onset before 16 years of age differs from adult-onset AS (AAS) in many respects.
objectiveTo compare the clinical features in JAS with different B27 subtypes and analyze the differences between JAS and AAS.
methods145 JAS and 360 AAS patients were included. The demographic data, clinical manifestations, laboratory markers, Bath AS indices, and B27 subtypes were recorded.
resultsPeripheral arthritis, enthesitis, BASDAI, ESR, and CRP were significantly higher in JAS patients with HLA-B(*)2704 than those with B27-negative. Enthesitis and ESR were significantly higher in patients with HLA-B(*)2705 than those with B27-negative. The onset age of HLA-B(*)2715 group was much earlier than the other groups. The peripheral arthritis, enthesitis, and hip joint involvement in JAS with HLA-B(*)2704 were significantly higher than those in AAS with HLA-B(*)2704.
conclusionJAS with different B27 subtypes had similar features in most of manifestations; JAS and AAS patients with the same subtype could have distinctive courses. Early diagnosis, hip detection, and control of systemic active inflammation in JAS patients will be helpful for improving the prognosis.
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