ReviewBioMed research international2015
The Potential Role of Iron and Copper in Pediatric Obesity and Nonalcoholic Fatty Liver Disease.
Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 45 citations in OpenAlex.
- Influence of endurance and endurance-strength training on mineral status in women with abdominal obesity: a randomized trial.Medicine · 2019Trial
- Diagnosis and Management of Pediatric Non-Alcoholic Fatty Liver Disease: An Overview.Metabolites · 2025Review
- The Interplay Between Iron Metabolism and Insulin Resistance: A Key Factor in Optimizing Obesity Management in Children and Adolescents.Nutrients · 2025Review
- Ultrafine garlic powder alleviates non-alcoholic steatohepatitis by inhibiting hepatocyte ferroptosis and modulating ERK-dependent oxidative stress.Frontiers in pharmacology · 2025Article
- Cuproptosis Cell Death Molecular Events and Pathways to Liver Disease.Journal of inflammation research · 2025Review
- Overweight, Obesity, Hypertriglyceridemia, and Insulin Resistance Are Positively Associated with High Serum Copper Levels in Mexican Adults.Metabolites · 2024Article
- Arbutin alleviates fatty liver by inhibiting ferroptosis via FTO/SLC7A11 pathway.Redox biology · 2023Article
- Micronutrient Deficiency in Children and Adolescents with Obesity-A Narrative Review.Children (Basel, Switzerland) · 2023Review
- Iron overload accelerated lipid metabolism disorder and liver injury in rats with non-alcoholic fatty liver disease.Frontiers in nutrition · 2022Article
- Recent advances in the application of ionomics in metabolic diseases.Frontiers in nutrition · 2022Review
- Article
- Serum Ferritin Correlates With Liver Fat in Male Adolescents With Obesity.Frontiers in endocrinology · 2020Article
- Adipocyte-specific disruption of ATPase copper transporting α in mice accelerates lipoatrophy.Diabetologia · 2019Article
- Five Constituents inFrontiers in pharmacology · 2019Article
- Microarray Expression Profiling and Raman Spectroscopy Reveal Anti-Fatty Liver Action of Berberine in a Diet-Induced Larval Zebrafish Model.Frontiers in pharmacology · 2019Article
- Macrophage Function in the Pathogenesis of Non-alcoholic Fatty Liver Disease: The Mac Attack.Frontiers in immunology · 2019Review
- Cross-sectional correlation between hepatic R2* and proton density fat fraction (PDFF) in children with hepatic steatosis.Journal of magnetic resonance imaging : JMRI · 2018Article
- Low Hepatic Tissue Copper in Pediatric Nonalcoholic Fatty Liver Disease.Journal of pediatric gastroenterology and nutrition · 2017Article
- Fat content, fatty acid pattern and iron content in livers of turkeys with hepatic lipidosis.Lipids in health and disease · 2017Article
- In vivo bioluminescence imaging reveals copper deficiency in a murine model of nonalcoholic fatty liver disease.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is a rapidly growing health problem and is paralleled by a multitude of comorbidities, including nonalcoholic fatty liver disease (NAFLD). NAFLD has become the most common chronic liver disease in both adults and children. The current understanding of NAFLD is still fragmentary. While simple steatosis is characterized by the interplay between excessive free fatty acid accumulation and hepatic insulin resistance, the progression to NASH has been related to oxidative stress and a proinflammatory state with dysbalanced adipokine, cytokine levels, and endotoxin-mediated immune response. In addition, oxidative stress has been suggested to play a central role for the sequelae leading to NASH. Trace elements are critical in regulatory, immunologic, and antioxidant functions resulting in protection against inflammation and peroxidation and consequently against the known comorbidities of obesity. Disruptions of the metal detoxification processes located in the liver are plausibly related to NAFLD development via oxidative stress. Perturbations of iron and copper (Cu) homeostasis have been shown to contribute to the pathogenesis of NAFLD. This review presents current data from pediatric studies. In addition, data from adult studies are summarized where clinical relevance may be extrapolated to pediatric obesity and NAFLD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.