Evidence map›Paper›PMID 26273541›Full record

ReviewBone research2015

Contemporary approaches for imaging skeletal metastasis.

David Ulmert, Lilja Solnes, Daniel Lj Thorek

Open access · goldAbstract readReview
In one paragraph

Review in Bone research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.6field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 43 citations in OpenAlex.

  1. Evaluation of Safety and Dosimetry ofJournal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021
    Trial
  2. Article
  3. The performance ofScientific reports · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Novel Agents and Future Perspectives on Theranostics.Seminars in radiation oncology · 2021
    Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Anatomic and Molecular Imaging in Prostate Cancer.Cold Spring Harbor perspectives in medicine · 2018
    Review
  14. 3D skeletal uptake ofEJNMMI research · 2017
    Article
  15. Bone Pain and Muscle Weakness in Cancer Patients.Current osteoporosis reports · 2017
    Review
  16. Review
  17. Article
  18. Article
  19. Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone.Matrix biology : journal of the International Society for Matrix Biology
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

David UlmertProgram in Molecular Pharmacology and Chemistry, Memorial Sloan Kettering Cancer Center , New York, NY, USA ; Department of Surgery, Skåne University Hospital , Lund, Sweden.
Lilja SolnesDivision of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Daniel Lj ThorekDivision of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine , Baltimore, MD, USA ; Department of Oncology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine , Baltimore, MD, USA.
Johns Hopkins Medicine · USJohns Hopkins University · USMemorial Sloan Kettering Cancer Center · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
SPORE In Prostate CancerP50CA092629 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI JAMES A EASTHAM · 2001 to 2026
$63.0M
TRANSGENIC MODELS FOR PROSTATE CANCER AND AUTOIMMUNITYP50CA058236 · NCI · JOHNS HOPKINS UNIVERSITY · PI DENMEADE, SAMUEL R · 1992 to 2020
$43.9M
VACCINIA PSA FOR ANDROGEN-MODULATED POST-SURGICAL RECURRENCE OF PROSTATE CANCERP50CA069568 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI CHINNAIYAN, ARUL M · 1995 to 2013
$31.3M
Tumor Evolution and Changes in MetabolismP50CA086438 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI LARSON, STEVEN MARK · 2000 to 2015
$29.9M
NCI NIH HHS P30 CA008748NCI NIH HHS P50 CA058236NCI NIH HHS P50 CA069568NCI NIH HHS P50 CA086438NCI NIH HHS P50 CA092629
6 · The paper itself

Abstract

The skeleton is a common site of cancer metastasis. Notably high incidences of bone lesions are found for breast, prostate, and renal carcinoma. Malignant bone tumors result in significant patient morbidity. Identification of these lesions is a critical step to accurately stratify patients, guide treatment course, monitor disease progression, and evaluate response to therapy. Diagnosis of cancer in the skeleton typically relies on indirect bone-targeted radiotracer uptake at sites of active bone remodeling. In this manuscript, we discuss established and emerging tools and techniques for detection of bone lesions, quantification of skeletal tumor burden, and current clinical challenges.

Identifiers

PMID26273541
PMCPMC4502405
OpenAlexW2132310957

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.