Evidence map›Paper›PMID 26273539›Full record

ArticleBone research2015

The effect of the fibre orientation of electrospun scaffolds on the matrix production of rabbit annulus fibrosus-derived stem cells.

Chen Liu, Caihong Zhu, Jun Li, Pinghui Zhou, Min Chen, Huilin Yang, Bin Li

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bone research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 98 citations in OpenAlex.

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  5. Optimization of 3D printing andFrontiers in bioengineering and biotechnology · 2023
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  19. Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration.Frontiers in bioengineering and biotechnology · 2021
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chen LiuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China ; Orthopedic Institute, Soochow University , 708 Renmin Rd, Suzhou, Jiangsu 215007, China.
Caihong ZhuDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China ; Orthopedic Institute, Soochow University , 708 Renmin Rd, Suzhou, Jiangsu 215007, China.
Jun LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China.
Pinghui ZhouDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China.
Min ChenDan F. Smith Department of Chemical Engineering, Lamar University , Beaumont, TX 77710, USA.
Huilin YangDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China ; Orthopedic Institute, Soochow University , 708 Renmin Rd, Suzhou, Jiangsu 215007, China.
Bin LiDepartment of Orthopaedics, The First Affiliated Hospital of Soochow University , 188 Shizi St, Suzhou, Jiangsu 215006, China ; Orthopedic Institute, Soochow University , 708 Renmin Rd, Suzhou, Jiangsu 215007, China.
First Affiliated Hospital of Soochow University · CNSoochow University · CNLamar University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Annulus fibrosus (AF) tissue engineering has recently received increasing attention as a treatment for intervertebral disc (IVD) degeneration; however, such engineering remains challenging because of the remarkable complexity of AF tissue. In order to engineer a functional AF replacement, the fabrication of cell-scaffold constructs that mimic the cellular, biochemical and structural features of native AF tissue is critical. In this study, we fabricated aligned fibrous polyurethane scaffolds using an electrospinning technique and used them for culturing AF-derived stem/progenitor cells (AFSCs). Random fibrous scaffolds, also prepared via electrospinning, were used as a control. We compared the morphology, proliferation, gene expression and matrix production of AFSCs on aligned scaffolds and random scaffolds. There was no apparent difference in the attachment or proliferation of cells cultured on aligned scaffolds and random scaffolds. However, compared to cells on random scaffolds, the AFSCs on aligned scaffolds were more elongated and better aligned, and they exhibited higher gene expression and matrix production of collagen-I and aggrecan. The gene expression and protein production of collagen-II did not appear to differ between the two groups. Together, these findings indicate that aligned fibrous scaffolds may provide a favourable microenvironment for the differentiation of AFSCs into cells similar to outer AF cells, which predominantly produce collagen-I matrix.

Identifiers

PMID26273539
PMCPMC4472148
OpenAlexW2396904210

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.