Evidence map›Paper›PMID 26273509›Full record

ReviewBone research2013

Skeletal Blood Flow in Bone Repair and Maintenance.

Ryan E Tomlinson, Matthew J Silva

Open access · bronzeAbstract readReview
In one paragraph

Review in Bone research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 133 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
133citing papers in PubMed, 1 pooled it
2.4field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

133 citing papers in PubMed, 1 synthesis or guideline pooled it, 283 citations in OpenAlex.

  1. A Beginner's Guide for Using Bone in Marine Mammal Research.Integrative and comparative biology · 2026
    Guideline
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73 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ryan E TomlinsonDepartment of Orthopaedic Surgery, Washington University in St. Louis , Saint Louis, MO, USA ; Musculoskeletal Research Center, Washington University in St. Louis , Saint Louis, MO, USA.
Matthew J SilvaDepartment of Orthopaedic Surgery, Washington University in St. Louis , Saint Louis, MO, USA ; Musculoskeletal Research Center, Washington University in St. Louis , Saint Louis, MO, USA.
Washington University in St. Louis · US

Funding

The Role of the Osteoblast Secretome in Bone FormationP30AR057235 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2009 to 2018
$5.7M
OSTEOGENIC AND ANGIOGENIC RESPONSE TO SKELETAL LOADINGR01AR050211 · NIAMS · WASHINGTON UNIVERSITY · PI SILVA, MATTHEW J · 2003 to 2020
$5.0M
NIAMS NIH HHS P30 AR057235NIAMS NIH HHS R01 AR050211
6 · The paper itself

Abstract

Bone is a highly vascularized tissue, although this aspect of bone is often overlooked. In this article, the importance of blood flow in bone repair and regeneration will be reviewed. First, the skeletal vascular anatomy, with an emphasis on long bones, the distinct mechanisms for vascularizing bone tissue, and methods for remodeling existing vasculature are discussed. Next, techniques for quantifying bone blood flow are briefly summarized. Finally, the body of experimental work that demonstrates the role of bone blood flow in fracture healing, distraction osteogenesis, osteoporosis, disuse osteopenia, and bone grafting is examined. These results illustrate that adequate bone blood flow is an important clinical consideration, particularly during bone regeneration and in at-risk patient groups.

Indexed as

angiogenesisblood flowbone repairfracturevascular remodeling

Identifiers

PMID26273509
PMCPMC4472118
OpenAlexW8711066

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.