ArticleBone research2013
New Clues that May Link Osteoporosis to the Circulating Lipid Profile.
Article in Bone research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Metabolomic biomarkers of low BMD: a systematic review.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2021Pooled it
- Osteoking exerts pro‑osteogenic and anti‑adipogenic effects in promoting bone fracture healing via EGF/EGFR/HDAC1/Wnt/β‑catenin signaling.International journal of molecular medicine · 2025Article
- Correlation between serum high-density lipoprotein cholesterol and bone mineral density in vitamin D-deficient populations.Journal of bone and mineral metabolism · 2025Article
- Acute hyperlipidemia has transient effects on large-scale bone regeneration in male mice.Scientific reports · 2024Article
- The impact of bone mineral density on the risk of falling: evidence from genetic correlation and Mendelian randomization analysis.Endocrine · 2024Article
- Article
- Gene Set Based Integrated Methylome and Transcriptome Analysis Reveals Potential Molecular Mechanisms Linking Cigarette Smoking and Related Diseases.Omics : a journal of integrative biology · 2023Article
- Neuroendocrine neoplasia and bone (Review).Experimental and therapeutic medicine · 2021Review
- Hypertension is associated with osteoporosis: a case-control study in Chinese postmenopausal women.BMC musculoskeletal disorders · 2021Article
- Osteopenia-osteoporosis discrimination in postmenopausal women by 1H NMR-based metabonomics.PloS one · 2019Article
- Correlation of the Lipid Profile, BMI and Bone Mineral Density in Postmenopausal Women.Materia socio-medica · 2016Article
- Glucocorticoids and Trabecular Bone Score.Journal of medicine and lifeReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone Mineral Density (BMD) is a gold standard for the diagnosis of osteoporosis and is also important in the assessment of fracture risk. Other risk factors have been identified that together make up fracture risk assessment tools such as FRAX. Another potential factor, circulating lipids, has been suggested because of reports linking statins to fracture risk reduction. We analyzed the lipid profile in a cohort of women diagnosed with postmenopausal osteoporosis based on bone density determination: 610 women with osteoporosis (mean lumbar spine T-score -3.16±0.81, mean yrs. since menopause 15.79±8.9) were grouped according to age at evaluation (< 50 years, 51-60 years, 61-70 years, > 70 years), the presence/absence of a history of a fragility fracture, statin and/or antiresorptive drug use. There was no correlation between BMD and Body Mass Index (BMI: P>0.05, r (2)<0.02). However, when BMD was correlated with both BMI and the lipid profile (Triglycerides, Cholesterol, LDLc, HDLc), significant correlations were found in 5 cohorts: 51-60 years with fractures (n=61, r (2)=0.14, P<0.01), 61-70 years (n=201, r (2)=0.09, P<0.01) with fractures (n=88, r (2)=0.14, P<0.01) or without fractures (n=113, r (2)=0.24, P=0.02) and over 70 years (n=247, r (2)=0.11, P<0.01).
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Registered trials
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