ArticleOxidative medicine and cellular longevity2015
Reactive Oxygen Species Are Required for Human Mesenchymal Stem Cells to Initiate Proliferation after the Quiescence Exit.
Article in Oxidative medicine and cellular longevity, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 73 citations in OpenAlex.
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- Cellular Metabolic Responses to Copper Nanoparticles: Comparison Between Normal and Breast Cancer Cells.International journal of molecular sciences · 2025Article
- Superoxide signalling and antioxidant processing in the plant nucleus.Journal of experimental botany · 2024Review
- Multilineage differentiation potential in the infant adipose- and umbilical cord-derived mesenchymal stem cells.Journal of the Chinese Medical Association : JCMA · 2023Article
- Reconditioned monocytes are immunomodulatory and regulate inflammatory environment in sepsis.Scientific reports · 2023Article
- Hydrogen Cyanamide Causes Reversible G2/M Cell Cycle Arrest Accompanied by Oxidation of the Nucleus and Cytosol.Antioxidants (Basel, Switzerland) · 2023Article
- Metabolic regulation of quiescence in plants.The Plant journal : for cell and molecular biology · 2023Article
- Expected and Unexpected Effects of Pharmacological Antioxidants.International journal of molecular sciences · 2023Review
- Remodeling of the osteoimmune microenvironment after biomaterials implantation in murine tibia: Single-cell transcriptome analysis.Bioactive materials · 2023Article
- The bridge between cell survival and cell death: reactive oxygen species-mediated cellular stress.EXCLI journal · 2023Review
- Article
- Metabolic control of induced pluripotency.Frontiers in cell and developmental biology · 2023Review
- The mitochondrial protein OPA1 regulates the quiescent state of adult muscle stem cells.Cell stem cell · 2022Article
- The Effects of 5% 5-Aminolevulinic Acid Gel and Red Light (ALAD-PDT) on Human Fibroblasts and Osteoblasts.Gels (Basel, Switzerland) · 2022Article
- Comparison of the Infant and Adult Adipose-Derived Mesenchymal Stem Cells in Proliferation, Senescence, Anti-oxidative Ability and Differentiation Potential.Tissue engineering and regenerative medicine · 2022Article
- Trappc9 Deficiency Impairs the Plasticity of Stem Cells.International journal of molecular sciences · 2022Article
- Editorial: Crosslinking ROS signaling and stem cells.Frontiers in cell and developmental biology · 2022Article
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Authors and funding
14 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study focuses on the involvement of reactive oxygen species (ROS) in the process of mesenchymal stem cells "waking up" and entering the cell cycle after the quiescence. Using human endometrial mesenchymal stem cells (eMSCs), we showed that intracellular basal ROS level is positively correlated with the proliferative status of the cell cultures. Our experiments with the eMSCs synchronized in the G0 phase of the cell cycle revealed a transient increase in the ROS level upon the quiescence exit after stimulation of the cell proliferation. This increase was registered before the eMSC entry to the S-phase of the cell cycle, and elimination of this increase by antioxidants (N-acetyl-L-cysteine, Tempol, and Resveratrol) blocked G1-S-phase transition. Similarly, a cell cycle arrest which resulted from the antioxidant treatment was observed in the experiments with synchronized human mesenchymal stem cells derived from the adipose tissue. Thus, we showed that physiologically relevant level of ROS is required for the initiation of human mesenchymal stem cell proliferation and that low levels of ROS due to the antioxidant treatment can block the stem cell self-renewal.
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