Evidence map›Paper›PMID 26273304›Full record

ReviewStem cells international2015

Regenerative Translation of Human Blood-Vessel-Derived MSC Precursors.

William C W Chen, Bruno Péault, Johnny Huard

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Five Decades Later, Are Mesenchymal Stem Cells Still Relevant?Frontiers in bioengineering and biotechnology · 2020
    Review
  7. Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William C W ChenDepartment of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA ; Department of Orthopedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA ; Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA 15219, USA ; Research Laboratory of Electronics and Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Bruno PéaultCenter for Cardiovascular Science, Queen's Medical Research Institute, Edinburgh EH16 4TJ, UK ; MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh EH16 4UU, UK ; UCLA Orthopaedic Hospital, Department of Orthopaedic Surgery and David Geffen School of Medicine, University of California at Los Angeles, Los Angeles, CA 90095, USA.
Johnny HuardDepartment of Orthopedic Surgery, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA ; Stem Cell Research Center, University of Pittsburgh, Pittsburgh, PA 15219, USA ; McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15219, USA ; Medical School and Regenerative and Translational Medicine Institute, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.

Funding

Medical Research Council G1000816
6 · The paper itself

Abstract

Mesenchymal stem/stromal cells (MSCs) represent a promising adult progenitor cell source for tissue repair and regeneration. Their mysterious identity in situ has gradually been unveiled by the accumulating evidence indicating an association between adult multipotent stem/progenitor cells and vascular/perivascular niches. Using immunohistochemistry and fluorescence-activated cell sorting, we and other groups have prospectively identified and purified subpopulations of multipotent precursor cells associated with the blood vessels within multiple human organs. The three precursor subsets, myogenic endothelial cells (MECs), pericytes (PCs), and adventitial cells (ACs), are located, respectively, in the three structural tiers of typical blood vessels: intima, media, and adventitia. MECs, PCs, and ACs have been extensively characterized in prior studies and are currently under investigation for their therapeutic potentials in preclinical animal models. In this review, we will briefly discuss the identification, isolation, and characterization of these human blood-vessel-derived stem cells (hBVSCs) and summarize the current status of regenerative applications of hBVSC subsets.

Identifiers

PMID26273304
PMCPMC4529976

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.