ArticleNeuropsychiatric disease and treatment2015
Pain perception in schizophrenia: influence of neuropeptides, cognitive disorders, and negative symptoms.
Article in Neuropsychiatric disease and treatment, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 62 citations in OpenAlex.
- Pain sensitivity in patients with schizophrenia: a systematic review and meta-analysis.Actas espanolas de psiquiatria · 2023Pooled it
- RDoC Mechanisms Underlying Bodily Symptoms in Psychiatry: A Scoping Review.Psychology research and behavior management · 2026Review
- Inclusion in the cancer patient pathway among cancer patients with and without pre-existing mental or substance use disorders: a nationwide register-based study.BMC public health · 2025Article
- The Impact of Childhood Maltreatment on Central Pain Processing in Individuals With Psychosis.Bipolar disorders · 2025Article
- Behavioral characterization of triple-hit schizophrenia-like Lisket rats derived from the Long Evans strain through acute and chronic behavioral tests.Frontiers in psychiatry · 2025Article
- Sex-specific differences in the clinical profile among psychiatric patients with pulmonary Embolism: a hospital-based retrospective study.BMC pulmonary medicine · 2024Article
- Prescription opioid dispensing patterns among patients with schizophrenia or bipolar disorder.BMC psychiatry · 2024Observational
- From periphery immunity to central domain through clinical interview as a new insight on schizophrenia.Scientific reports · 2024Article
- Alterations of serum neuropeptide levels and their relationship to cognitive impairment and psychopathology in male patients with chronic schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Gene expression analysis of Schizophrenia.Bioinformation · 2024Article
- Plasma neuropeptide levels in patients with schizophrenia, bipolar disorder, or major depressive disorder and healthy controls: A multiplex immunoassay study.Neuropsychopharmacology reports · 2023Article
- Risks of complicated acute appendicitis in patients with psychiatric disorders.BMC psychiatry · 2022Article
- Higher amoebic and metronidazole resistant forms of Blastocystis sp. seen in schizophrenic patients.Parasites & vectors · 2022Article
- Chronic Pain: Among Tertiary Care Psychiatric Out-Patients in Singapore-Prevalence and Associations with Psychiatric Disorders.Pain research & management · 2022Article
- Atraumatic Bilateral Acute Compartment Syndrome of the Lower Legs: A Review of the Literature.Cureus · 2021Review
- Outpatient prescribing of opioids to adults diagnosed with mental disorders in the United States.Drug and alcohol dependence · 2021Article
- Guanosine ameliorates positive symptoms of schizophreniaAmerican journal of translational research · 2021Article
- The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids.Brain, behavior, & immunity - health · 2020Review
- Genome-wide association study of multisite chronic pain in UK Biobank.PLoS genetics · 2019Article
- Odor perception and hedonics in chronic schizophrenia and in first episode psychosis.Neuropsychiatric disease and treatment · 2019Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThe causes and nature of insensitivity to pain in schizophrenia remain unknown. The role of endorphins and the association of cognitive dysfunction and negative symptoms are postulated.
methodsIn this study, 43 patients with schizophrenia, five first-degree relatives, and 34 healthy controls were examined. Participants' plasma concentrations of substance P, β-endorphin, and calcitonin gene-related peptide (CGRP) were assessed. In patients, the Trail-Making Test, the Color Reading Interference Test (Stroop test), and the Positive and Negative Syndrome Scale Negative Syndrome subscale (PANSS N) test were performed. We also evaluated pain threshold using nociceptive reflex (RTIII) testing.
resultsThe mean β-endorphin concentration was about 20% higher in patients than in healthy controls (P<0.05). CGRP concentrations were significantly higher in patients than in controls (5.34 ng/mL versus 4.16 ng/mL; P<0.01). Subjects treated with antipsychotic polytherapy had higher concentrations of CGRP than did patients treated with second-generation antipsychotic monotherapy (5.92 ng/mL versus 5.02 ng/mL; P<0.05). There were no correlations between any biochemical parameters and Trail-Making Test, Stroop test, and PANSS N scores. There were no differences in RTIII among study groups. Strong negative correlation (P<0.001) was found between PANSS N scores and subjective pain threshold on the right lower limb.
conclusionThe insensitivity to pain in schizophrenia is a complex phenomenon that is probably not related to changes in nociceptive pathways. Increase in β-endorphin level may be related to this issue, but it is uncertain if such concentration ensures analgesic effect. It is unknown if patients with schizophrenia in fact experience less pain. Cognitive impairment and excess negative symptoms may strongly influence the patient's expression of pain.
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