ArticleArteriosclerosis, thrombosis, and vascular biology2015
Gallstone Disease and the Risk of Ischemic Heart Disease.
Registry-linked trialOpen access · greenAbstract read
In one paragraph
Article in Arteriosclerosis, thrombosis, and vascular biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05618626 (Cardiovascular Diseases), which is not on this map. Cited by 26 papers, 6 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 6 pooled it
4.8field-weighted citation impact, top 5% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cardiovascular Diseases (CVD) and Nonalcoholic Fatty Liver Diseases (NAFLD) Among Gallstone and Cholecystectomy Patients and the Impact of a Novel Diet and Muscle Training Program
Who cites it
26 citing papers in PubMed, 6 syntheses or guidelines pooled it, 51 citations in OpenAlex.
- Pooled it
- The Association between Gallstone Disease and Cardiovascular Disease: A Systematic Review and Meta-Analysis.Reviews on recent clinical trials · 2025Pooled it
- Impact of gallstone disease on the risk of stroke and coronary artery disease: evidence from prospective observational studies and genetic analyses.BMC medicine · 2023Pooled it
- Gallstone Disease and the Risk of Cardiovascular Disease.Scientific reports · 2019Pooled it
- The relation between gallstone disease and cardiovascular disease.Scientific reports · 2017Pooled it
- Gallstones and Risk of Coronary Heart Disease: Prospective Analysis of 270 000 Men and Women From 3 US Cohorts and Meta-Analysis.Arteriosclerosis, thrombosis, and vascular biology · 2016Pooled it
- Screen-detected gallstone disease and cardiovascular disease.European journal of epidemiology · 2017Trial
- Association between gallstones and subclinical coronary atherosclerosis: An observational study with propensity score matching.PloS one · 2026Observational
- The association between neutrophil to high-density lipoprotein cholesterol ratio and gallstones: a cross-sectional study.BMC public health · 2025Article
- Association between fecal incontinence and cardiovascular disease in adult Americans: evidence from NHANES 2005-2010.Frontiers in cardiovascular medicine · 2024Article
- Renal Stones and Gallstones Correlated with the Ten-Year Risk Estimation of Atherosclerotic Cardiovascular Disease Based on the Pooled Cohort Risk Assessment of Males Aged 40-79.Journal of clinical medicine · 2023Article
- Gallbladder disease is associated with the risk of cardiovascular disease among Uyghurs in Xinjiang: a prospective cohort study.BMC public health · 2023Article
- The association between hypertension and the risk of gallstone disease: a cross-sectional study.BMC gastroenterology · 2022Article
- Risk of acute atherosclerotic cardiovascular disease in patients with acute and chronic pancreatitis.Scientific reports · 2021Article
- Reduced Risk of Atrial Fibrillation Following Cholecystectomy: A Nationwide Population-Based Study.Frontiers in aging neuroscience · 2021Article
- The Risk of Venous Thromboembolism in Patients with Gallstones.International journal of environmental research and public health · 2020Article
- Association of Cholecystectomy with the Risk of Prostate Cancer in Patients with Gallstones.Cancers · 2020Article
- Association between gallstone and cardio-cerebrovascular disease: Systematic review and meta-analysis.Experimental and therapeutic medicine · 2019Article
- Gastrointestinal defects in gallstone and cholecystectomized patients.European journal of clinical investigation · 2019Article
- Evaluation of the cardiovascular risk in patients with biliary stones: a descriptive cross-sectional study.Gastroenterology and hepatology from bed to bench · 2018Article
Corrections and comments
- Commented on by
Authors and funding
16 authors at 1 institution in 2 countries.
Jun LvFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Lu QiFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.). lmlee@vip.163.com nhlqi@channing.harvard.edu.
Canqing YuFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Yu GuoFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Zheng BianFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Yiping ChenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Ling YangFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Jie ShenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Shanqing WangFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Mingqiang LiFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Yongmei LiuFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Libo ZhangFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Junshi ChenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Zhengming ChenFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.).
Liming LiFrom the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China (J.L., C.Y., L.L.); Department of Nutrition, Harvard School of Public Health, Boston, MA (L.Q.); Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA (L.Q.); Chinese Academy of Medical Sciences, Beijing, China (Y.G., Z.B., L.L.); Clinical Trial Service Unit & Epidemiological Studies Unit (CTSU), Nuffield Department of Population Health, University of Oxford, UK (Y.C., L.Y., Z.C.); Suzhou Sanitary Bureau, Suzhou, Jiangsu, China (J.S.); Hainan Center for Disease Control & Prevention, Haikou, Hainan, China (S.W.); Liuzhou Center for Disease Control & Prevention, Liuzhou, Guangxi, China (M.L.); Department of Non-communicable Disease Prevention & Control, Qingdao Center for Disease Control & Prevention, Qingdao, Shandong, China (Y.L.); Department of Non-communicable Disease Prevention & Control, Liuyang Center for Disease Control & Prevention, Changsha, Hunan, China (L.Z.); and China National Center for Food Safety Risk Assessment, Beijing, China (J.C.). lmlee@vip.163.com nhlqi@channing.harvard.edu.
China Kadoorie Biobank Collaborative Group*
Brigham and Women's Hospital · US
Funding
Transgenic CoreP30DK046200 · NIDDK · TUFTS MEDICAL CENTER · PI CORKEY, BARBARA E. · 1992 to 2021
$25.0MRISK FACTORS FOR CVD IN WOMENR01HL034594 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI JoAnn Elisabeth Manson, Lu Qi · 1985 to 2026
$13.8MCommon Genetic Variation and Quantitative Diabetes TraitsR01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2008 to 2014
$5.0MGenetic Markers of CHD in Type 2 DiabetesR01HL071981 · NHLBI · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI QI, LU · 2003 to 2012
$4.9MObesity Genes, Energy Regulation in Response to Weight-Loss DietsR01DK091718 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2012 to 2021
$4.5MWeight-Loss Diet Intervention on Cardiometabolic Factors of Gut MicrobiotaR01DK100383 · NIDDK · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2014 to 2024
$4.2MTOPMed Omics of Type 2 Diabetes and Quantitative TraitsUM1DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MANNING, ALISA KNODLE · 2021 to 2025
$3.8MRare Sequence Variation and Diabetes Quantitative TraitsU01DK078616 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI MEIGS, JAMES B · 2015 to 2019
$3.6MGenome-wide interactions with diet patterns on long-term weight changeR21HL126024 · NHLBI · TULANE UNIVERSITY OF LOUISIANA · PI QI, LU · 2015 to 2016
$421kMedical Research Council MC_U137686851NHLBI NIH HHS HL034594NHLBI NIH HHS HL071981NHLBI NIH HHS HL126024NHLBI NIH HHS R01 HL034594NHLBI NIH HHS R01 HL071981NHLBI NIH HHS R21 HL126024NIDDK NIH HHS DK078616NIDDK NIH HHS DK091718NIDDK NIH HHS DK100383NIDDK NIH HHS DK46200NIDDK NIH HHS P30 DK046200NIDDK NIH HHS R01 DK078616NIDDK NIH HHS R01 DK091718NIDDK NIH HHS R01 DK100383NIDDK NIH HHS U01 DK078616NIDDK NIH HHS UM1 DK078616Wellcome Trust 088158Wellcome Trust 104085
Abstract
objectiveGallstone disease (GSD) is related to multiple cardiovascular risk factors; the present study was to prospectively examine the association between GSD and ischemic heart disease (IHD). APPROACH AND
resultsWe examined the association of GSD with IHD among 199 292 men and 288 081 women aged 30-79 years in the China Kadoorie Biobank study. Participants with cancer, heart disease, and stroke at baseline were excluded. Cox proportional hazards regression model was used to estimate the association of GSD with IHD. The prevalence of self-reported GSD was 3.7% in men and 7.3% in women at baseline. During 3 431 124 person-years of follow-up between 2004 and 2013 (median, 7.2 years), we documented 10 245 incident IHD cases in men and 14 714 in women. As compared with men without GSD at baseline, the multivariate-adjusted hazard ratio for IHD was 1.11 (95% confidence interval, 1.02-1.22) for men with GSD; the respective hazard ratio was 1.27 (95% confidence interval, 1.20-1.34) in women and 1.23 (95% confidence interval, 1.17-1.28) in the whole cohort. The sex difference in IHD risk associated with GSD was statistically significant (P=0.009 for interaction with sex). In addition, we found that the association between GSD and IHD was stronger in nonhypertensive than in hypertensive women (P<0.001 for interaction).
conclusionsIn this large prospective study, the presence of GSD was associated with an increased risk of incident IHD, independent of other risk factors of cardiovascular disease. Our findings suggest novel prevention strategy to mitigate heart disease through improvement of gastrointestinal health.
Indexed as
AdultAgedAge DistributionChinaComorbidityConfidence IntervalsDatabases, FactualFemaleGallstonesHumansLongitudinal StudiesMaleMiddle AgedMultivariate AnalysisMyocardial IschemiaPrevalencecardiovascular diseaseChineseischemic heart diseaseslongitudinal cohort studyrisk factor
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05618626ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.