ArticleJournal of experimental botany2015
The Arabidopsis gene DIG6 encodes a large 60S subunit nuclear export GTPase 1 that is involved in ribosome biogenesis and affects multiple auxin-regulated development processes.
Article in Journal of experimental botany, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 25 citations in OpenAlex.
- Proteomic Analysis Reveals Accompanying Anion-Dependent Changes of Cadmium Toxicity During Arabidopsis thaliana Development.Plant, cell & environment · 2026Article
- Haplotype-Resolved Genome Assembly and Population Genomics Reveal Evolutionary History and Agronomic Traits of Mulberry.Plant biotechnology journal · 2026Article
- Ribosome biogenesis in plants requires the nuclear envelope and mitochondria localized OPENER complex.Nature communications · 2025Article
- DRMY1 promotes robust morphogenesis in Arabidopsis by sustaining the translation of cytokinin-signaling inhibitor proteins.Developmental cell · 2024Article
- Genome-wide association analysis reveal candidate genes and haplotypes related to root weight in cucumber (Frontiers in plant science · 2024Article
- Transcriptome and WGCNA reveal hub genes in sugarcane tiller seedlings in response to drought stress.Scientific reports · 2023Article
- The 2020 derecho revealed limited overlap between maize genes associated with root lodging and root system architecture.Plant physiology · 2023Article
- Transcriptomic Analysis of Radish (Plants (Basel, Switzerland) · 2022Article
- The nucleolar protein SAHY1 is involved in pre-rRNA processing and normal plant growth.Plant physiology · 2021Article
- Ribosome biogenesis factor OLI2 and its interactor BRX1-2 are associated with morphogenesis and lifespan extension inPlant biotechnology (Tokyo, Japan) · 2021Article
- Ribosome Biogenesis in Plants: From Functional 45S Ribosomal DNA Organization to Ribosome Assembly Factors.The Plant cell · 2019Review
- The complex genetic architecture of shoot growth natural variation in Arabidopsis thaliana.PLoS genetics · 2019Article
- Plant-specific ribosome biogenesis factors in Arabidopsis thaliana with essential function in rRNA processing.Nucleic acids research · 2019Article
- A Network-Guided Genetic Approach to Identify Novel Regulators of Adventitious Root Formation inFrontiers in plant science · 2019Article
- Salt hypersensitive mutant 9, a nucleolar APUM23 protein, is essential for salt sensitivity in association with the ABA signaling pathway in Arabidopsis.BMC plant biology · 2018Article
- Reading the Evolution of Compartmentalization in the Ribosome Assembly Toolbox: The YRG Protein Family.PloS one · 2017Article
- AtLSG1-2 Regulates Leaf Growth by Affecting Cell Proliferation and the Onset of Endoreduplication and Synergistically Interacts with AtNMD3 during Cell Proliferation Process.Frontiers in plant science · 2017Article
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Authors and funding
12 authors at 5 institutions in 4 countries.
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No grant is acknowledged in the PubMed record.
Abstract
The circularly permuted GTPase large subunit GTPase 1 (LSG1) is involved in the maturation step of the 60S ribosome and is essential for cell viability in yeast. Here, an Arabidopsis mutant dig6 (drought inhibited growth of lateral roots) was isolated. The mutant exhibited multiple auxin-related phenotypes, which included reduced lateral root number, altered leaf veins, and shorter roots. Genetic mapping combined with next-generation DNA sequencing identified that the mutation occurred in AtLSG1-2. This gene was highly expressed in regions of auxin accumulation. Ribosome profiling revealed that a loss of function of AtLSG1-2 led to decreased levels of monosomes, further demonstrating its role in ribosome biogenesis. Quantitative proteomics showed that the expression of certain proteins involved in ribosome biogenesis was differentially regulated, indicating that ribosome biogenesis processes were impaired in the mutant. Further investigations showed that an AtLSG1-2 deficiency caused the alteration of auxin distribution, response, and transport in plants. It is concluded that AtLSG1-2 is integral to ribosome biogenesis, consequently affecting auxin homeostasis and plant development.
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