ArticlePlant physiology2015
Natural Variation of Plant Metabolism: Genetic Mechanisms, Interpretive Caveats, and Evolutionary and Mechanistic Insights.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Metabolic plasticity and adaptive evolution inFrontiers in plant science · 2025Review
- Genome-Wide Transcriptomic and Metabolomic Analyses Unveiling the Defence Mechanisms ofInternational journal of molecular sciences · 2024Article
- The RNA-Binding Protein BoRHON1 Positively Regulates the Accumulation of Aliphatic Glucosinolates in Cabbage.International journal of molecular sciences · 2024Article
- Genome-wide association studies identify loci controlling specialized seed metabolites in Arabidopsis.Plant physiology · 2024Article
- The potential of metabolomics in assessing global compositional changes resulting from the application of CRISPR/Cas9 technologies.Transgenic research · 2023Article
- Combined Transcriptome and Metabolome Analysis Reveals Adaptive Defense Responses to DON Induction in Potato.International journal of molecular sciences · 2023Article
- Article
- Generalizable approaches for genomic prediction of metabolites in plants.The plant genome · 2022Article
- Selection for seed size has uneven effects on specialized metabolite abundance in oat (Avena sativa L.).G3 (Bethesda, Md.) · 2022Article
- Article
- Genome-wide association studies: assessing trait characteristics in model and crop plants.Cellular and molecular life sciences : CMLS · 2021Review
- SNPeffect: identifying functional roles of SNPs using metabolic networks.The Plant journal : for cell and molecular biology · 2020Article
- Association analysis of phenotypic and metabolomic changes in Arabidopsis accessions and their FPlant biotechnology (Tokyo, Japan) · 2019Article
- Statistical study on the environmental effects on the natural variation of nutritional components in rice varieties.Food science & nutrition · 2019Article
- Dark period transcriptomic and metabolic profiling of two diversePlant direct · 2018Article
- Natural Variation in Elicitation of Defense-Signaling Associates to Field Resistance Against the Spot Blotch Disease in Bread Wheat (Frontiers in plant science · 2018Article
- Metabolite Profiles of Sugarcane Culm Reveal the Relationship Among Metabolism and Axillary Bud Outgrowth in Genetically Related Sugarcane Commercial Cultivars.Frontiers in plant science · 2018Article
- Genetic dissection of metabolite variation in Arabidopsis seeds: evidence for mQTL hotspots and a master regulatory locus of seed metabolism.Journal of experimental botany · 2017Article
- Similarities between plant traits based on their connection to underlying gene functions.PloS one · 2017Article
- Integrating metabolomics and transcriptomics data to discover a biocatalyst that can generate the amine precursors for alkamide biosynthesis.The Plant journal : for cell and molecular biology · 2016Article
Corrections and comments
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Authors and funding
2 authors.
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Abstract
Combining quantitative genetics studies with metabolomics/metabolic profiling platforms, genomics, and transcriptomics is creating significant progress in identifying the causal genes controlling natural variation in metabolite accumulations and profiles. In this review, we discuss key mechanistic and evolutionary insights that are arising from these studies. This includes the potential role of transport and other processes in leading to a separation of the site of mechanistic causation and metabolic consequence. A reilluminated observation is the potential for genomic variation in the organelle to alter phenotypic variation alone and in epistatic interaction with the nuclear genetic variation. These studies are also highlighting new aspects of metabolic pleiotropy both in terms of the breadth of loci altering metabolic variation as well as the potential for broader effects on plant defense regulation of the metabolic variation than has previously been predicted. We also illustrate caveats that can be overlooked when translating quantitative genetics descriptors such as heritability and per-locus r(2) to mechanistic or evolutionary interpretations.
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