ArticleThe journal of headache and pain2015
Migraine and restless legs syndrome are associated in adults under age fifty but not in adults over fifty: a population-based study.
Article in The journal of headache and pain, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 4 of them syntheses that pooled it.
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Who cites it
23 citing papers in PubMed, 4 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Migraine and Restless Legs Syndrome: A Meta-Analysis.Journal of sleep research · 2026Pooled it
- Comorbidities of primary headache disorders: a literature review with meta-analysis.The journal of headache and pain · 2021Pooled it
- The Prevalence of Restless Legs Syndrome in Patients with Migraine: A Systematic Review and Meta-Analysis.Pain research & management · 2020Pooled it
- Prevalence of restless legs syndrome in individuals with migraine: a systematic review and meta-analysis of observational studies.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2018Pooled it
- Restless Legs Syndrome and Neurological Comorbidities: A Narrative Review.Journal of clinical medicine · 2026Review
- Clinical impact of restless legs syndrome in patients with migraine: a 12-year, single-center, longitudinal study.Sleep and biological rhythms · 2025Article
- The Impact of Age and Body Composition on Bone Density among Office Worker Women in Hungary.International journal of environmental research and public health · 2023Article
- Sleep state of the elderly population in Korea: Nationwide cross-sectional population-based study.Frontiers in neurology · 2022Article
- Central sensitization in migraine is related to restless legs syndrome.Journal of neurology · 2021Article
- Self-reported insomnia as a marker for anxiety and depression among migraineurs: a population-based cross-sectional study.Scientific reports · 2019Article
- The Comorbidity of Migraine and Restless Legs Syndrome.Current neurology and neuroscience reports · 2019Review
- Excessive Daytime Sleepiness in Tension-Type Headache: A Population Study.Frontiers in neurology · 2019Article
- Insufficient Sleep in Tension-Type Headache: A Population Study.Journal of clinical neurology (Seoul, Korea) · 2018Article
- Impact of migraine on the clinical presentation of insomnia: a population-based study.The journal of headache and pain · 2018Article
- Altered Brain Functional Connectome in Migraine with and without Restless Legs Syndrome: A Resting-State Functional MRI Study.Frontiers in neurology · 2018Article
- Restless legs syndrome and tension-type headache: a population-based study.The journal of headache and pain · 2017Article
- Insufficient sleep is prevalent among migraineurs: a population-based study.The journal of headache and pain · 2017Article
- Insomnia in tension-type headache: a population-based study.The journal of headache and pain · 2017Article
- Excessive daytime sleepiness is associated with an exacerbation of migraine: A population-based study.The journal of headache and pain · 2016Article
- Prevalence of restless legs syndrome in migraine patients with and without aura: a cross-sectional, case-controlled study.The journal of headache and pain · 2016Article
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent studies have shown an association between migraine and restless legs syndrome (RLS). However, migraine prevalence peaks from the 20s to 40s whereas RLS prevalence peaks after the 50s. Despite this, reports on how migraine and RLS may be associated by age is limited. Therefore, the purpose of this study is to investigate the comorbidity between migraine and RLS according to age.
methodsWe selected a stratified random population sample of Koreans aged 19 to 69 years and evaluated them with a 60-item semi-structured interview designed to identify RLS, headache type, and clinical characteristics of migraine. To assess the association between migraine and RLS according to age, we divided participants into 5 age groups (19-29, 30-39, 40-49, 50-59, and 60-69 years) and analysed each group.
resultsSubjects with migraine showed an increased RLS prevalence in the 19-29 (Odds ratio [OR] = 6.6, 95 % confidence interval [CI] = 1.2-36.8) and 40-49 (OR = 6.7, 95 % CI = 1.5-33.5) age groups compared to non-headache controls but failed to showed a significant association in the 50-59 (OR = 1.1, 95 % CI = 0.2-5.6) and 60-69 (OR = 0.4, 95 % CI = 0.1-4.0) age groups. Migraineurs with 1-10 (12.5 %, OR = 2.0, 95 % CI = 1.3-3.2, p = 0.003) and >10 (12.5 %, OR = 2.5, 95 % CI = 1.0-5.6, p = 0.038) attacks per month showed an increased RLS prevalence compared to migraineurs with <1 attack per month (2.1 %). Subjects with non-migraine headaches showed an increased odds for RLS (OR = 1.8, 95 % CI = 1.3-2.7) compared to non-headache controls. There was no significant difference (9.1 % vs. 6.9 %, p = 0.339) in the RLS prevalence between migraineurs and non-migraine headache subjects.
conclusionsOur results suggest that migraine and RLS are differently associated according to age.
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