ArticleHeart rhythm2016
Effect of mental stress on dynamic electrophysiological properties of the endocardium and epicardium in humans.
Article in Heart rhythm, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Acute hydrocortisone administration reduces cardiovagal baroreflex sensitivity and heart rate variability in young men.The Journal of physiology · 2018Trial
- Heart-brain axis pathophysiological understanding and clinical impact.Frontiers in cardiovascular medicine · 2026Review
- Surgical Implant Procedure and Wiring Configuration for Continuous Long-Term EEG/ECG Monitoring in Rabbits.Journal of visualized experiments : JoVE · 2025Article
- Study on different brain activation rearrangement during cognitive workload from ERD/ERS and coherence analysis.Cognitive neurodynamics · 2024Article
- Psychological stress, the central nervous system and arrhythmias.QJM : monthly journal of the Association of Physicians · 2023Review
- Investigation of the neural correlation with task performance and its effect on cognitive load level classification.PloS one · 2023Article
- The Impact of Mental Stress on Cardiovascular Health-Part II.Journal of clinical medicine · 2022Review
- Diagnostic Imaging Analysis and Care of Patients with Endomyocardial Fibrosis Based on Wireless Network Smart Medical Application.Journal of healthcare engineering · 2022Article
- Validity of the Polar V800 Monitor for Assessing Heart Rate Variability in Elderly Adults under Mental Stress and Dual Task Conditions.International journal of environmental research and public health · 2021Article
- Article
- The Effect of Emotional Valence on Ventricular Repolarization Dynamics Is Mediated by Heart Rate Variability: A Study of QT Variability and Music-Induced Emotions.Frontiers in physiology · 2019Article
- Detrended Fluctuation, Coherence, and Spectral Power Analysis of Activation Rearrangement in EEG Dynamics During Cognitive Workload.Frontiers in human neuroscience · 2019Article
- Insight into specific pro-arrhythmic triggers in Brugada and early repolarization syndromes: results of long-term follow-up.Heart and vessels · 2016Article
- Mental Stress and Ventricular Arrhythmias.Current cardiology reports · 2016Review
- The role of GαO-mediated signaling in the rostral ventrolateral medulla oblongata in cardiovascular reflexes and control of cardiac ventricular excitability.Physiological reports · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundStriking temporal associations exist between ventricular arrhythmia and acute mental stress, for example, during natural disasters, or defibrillator shocks associated with stressful events. We hypothesized that electrophysiological changes in response to mental stress may be exaggerated at short coupling intervals and hence relevant to arrhythmia initiation.
objectiveThe aim of this study was to determine the dynamic response in human electrophysiology during mental stress.
methodsPatients with normal hearts and supraventricular tachycardia underwent electrophysiological studies avoiding sedation. Conditions of relaxation and stress were induced with standardized psychometric protocols (mental arithmetic and anger recall) during decremental S1S2 right ventricular (RV) pacing. Unipolar electrograms were acquired simultaneously from the RV endocardium, left ventricular (LV) endocardium (LV endo), and epicardium (LV epi), and activation-recovery intervals (ARIs) computed.
resultsTwelve patients ( 9 women; median age 34 years) were studied. During stress, effective refractory period (ERP) reduced from 228 ± 23 to 221 ± 21 ms (P < .001). ARIs reduced during mental stress (P < .001), with greater reductions in LV endocardium than in the epicardium or RV endocardium (LV endo -8 ms; LV epi -5 ms; RV endo -4 ms; P < .001). Mental stress depressed the entire electrical restitution curve, with minimal effect on slope. A substantial reduction in minimal ARIs on the restitution curve in LV endo occurred, commensurate with the reduction in ERP (LV endo ARI 195 ± 31 ms at rest to 182 ± 32 ms during mental stress; P < .001). Dispersion of repolarization increased sharply at coupling intervals approaching ERP during stress but not at rest.
conclusionMental stress induces significant electrophysiological changes. The increase in dispersion of repolarization at short coupling intervals may be relevant to observed phenomena of arousal-associated arrhythmia.
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