ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Quadriceps exercise intolerance in patients with chronic obstructive pulmonary disease: the potential role of altered skeletal muscle mitochondrial respiration.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
28 citing papers in PubMed, 40 citations in OpenAlex.
- Review
- Mitochondrial Mechanisms of Resistance Exercise in COPD-Related Skeletal Muscle Dysfunction: A Narrative Review.International journal of chronic obstructive pulmonary disease · 2026Review
- Chamber oxygen concentration impacts mitochondrial function and hydrogen peroxide appearance in permeabilized human skeletal muscle fibers.Biochimica et biophysica acta. Bioenergetics · 2025Article
- Glycocalyx-targeted therapy prevents age-related muscle loss and declines in maximal exercise capacity.Aging · 2025Article
- Mitochondrial Dysfunction and Defects in Mitochondrial Adaptation to Exercise Training in the Muscle of Patients With COPD: Disease Versus Disuse.Acta physiologica (Oxford, England) · 2025Article
- Succinate dehydrogenase-complex II regulates skeletal muscle cellular respiration and contractility but not muscle mass in genetically induced pulmonary emphysema.Science advances · 2024Article
- Main Pathogenic Mechanisms and Recent Advances in COPD Peripheral Skeletal Muscle Wasting.International journal of molecular sciences · 2023Review
- Whole-body and muscle responses to aerobic exercise training and withdrawal in ageing and COPD.The European respiratory journal · 2022Article
- Article
- Acute high-intensity exercise and skeletal muscle mitochondrial respiratory function: role of metabolic perturbation.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- Skeletal muscle mitochondrial adaptations induced by long-term cigarette smoke exposure.American journal of physiology. Endocrinology and metabolism · 2021Article
- Functional, proteomic and bioinformatic analyses of Nrf2- and Keap1- null skeletal muscle.The Journal of physiology · 2020Article
- The effect of succinic acid on the metabolic profile in high-fat diet-induced obesity and insulin resistance.Physiological reports · 2020Article
- Determinants of the diminished exercise capacity in patients with chronic obstructive pulmonary disease: looking beyond the lungs.The Journal of physiology · 2020Article
- Locomotor Muscles in COPD: The Rationale for Rehabilitative Exercise Training.Frontiers in physiology · 2019Review
- Acute High-Intensity Exercise Impairs Skeletal Muscle Respiratory Capacity.Medicine and science in sports and exercise · 2018Article
- Vascular mitochondrial respiratory function: the impact of advancing age.American journal of physiology. Heart and circulatory physiology · 2018Article
- Increased skeletal muscle mitochondrial free radical production in peripheral arterial disease despite preserved mitochondrial respiratory capacity.Experimental physiology · 2018Article
- Altered skeletal muscle mitochondrial phenotype in COPD: disease vs. disuse.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Resveratrol for patients with chronic obstructive pulmonary disease: hype or hope?Current opinion in clinical nutrition and metabolic care · 2018Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
This study sought to determine if qualitative alterations in skeletal muscle mitochondrial respiration, associated with decreased mitochondrial efficiency, contribute to exercise intolerance in patients with chronic obstructive pulmonary disease (COPD). Using permeabilized muscle fibers from the vastus lateralis of 13 patients with COPD and 12 healthy controls, complex I (CI) and complex II (CII)-driven State 3 mitochondrial respiration were measured separately (State 3:CI and State 3:CII) and in combination (State 3:CI+CII). State 2 respiration was also measured. Exercise tolerance was assessed by knee extensor exercise (KE) time to fatigue. Per milligram of muscle, State 3:CI+CII and State 3:CI were reduced in COPD (P < 0.05), while State 3:CII and State 2 were not different between groups. To determine if this altered pattern of respiration represented qualitative changes in mitochondrial function, respiration states were examined as percentages of peak respiration (State 3:CI+CII), which revealed altered contributions from State 3:CI (Con 83.7 ± 3.4, COPD 72.1 ± 2.4%Peak, P < 0.05) and State 3:CII (Con 64.9 ± 3.2, COPD 79.5 ± 3.0%Peak, P < 0.05) respiration, but not State 2 respiration in COPD. Importantly, a diminished contribution of CI-driven respiration relative to the metabolically less-efficient CII-driven respiration (CI/CII) was also observed in COPD (Con 1.28 ± 0.09, COPD 0.81 ± 0.05, P < 0.05), which was related to exercise tolerance of the patients (r = 0.64, P < 0.05). Overall, this study indicates that COPD is associated with qualitative alterations in skeletal muscle mitochondria that affect the contribution of CI and CII-driven respiration, which potentially contributes to the exercise intolerance associated with this disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.