ArticleJournal of applied physiology (Bethesda, Md. : 1985)2015
Tetraplegia is associated with enhanced peripheral chemoreflex sensitivity and ventilatory long-term facilitation.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 38 citations in OpenAlex.
- The hypoxic ventilatory response and hypoxic burden are predictors of the magnitude of ventilatory long-term facilitation in humans.The Journal of physiology · 2023Pooled it
- Cardiorespiratory Responses to Acute Intermittent Hypoxia in Humans With Chronic Spinal Cord Injury.Journal of neurotrauma · 2024Trial
- Single-session effects of acute intermittent hypoxia on breathing function after human spinal cord injury.Experimental neurology · 2021Trial
- Mirtazapine reduces susceptibility to hypocapnic central sleep apnea in males with sleep-disordered breathing: a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2021Trial
- Effect of acetazolamide on susceptibility to central sleep apnea in chronic spinal cord injury.Journal of applied physiology (Bethesda, Md. : 1985) · 2020Trial
- Positive airway pressure for sleep-disordered breathing in acute quadriplegia: a randomised controlled trial.Thorax · 2019Trial
- An update on spinal cord injury and diaphragm neuromotor control.Expert review of respiratory medicine · 2025Review
- Respiratory plasticity following spinal cord injury: perspectives from mouse to man.Neural regeneration research · 2022Review
- Tetraplegia is associated with increased hypoxic ventilatory response during nonrapid eye movement sleep.Physiological reports · 2022Article
- Therapeutic acute intermittent hypoxia: A translational roadmap for spinal cord injury and neuromuscular disease.Experimental neurology · 2022Review
- A comprehensive review of respiratory, autonomic and cardiovascular responses to intermittent hypoxia in humans.Experimental neurology · 2021Review
- Respiratory Training and Plasticity After Cervical Spinal Cord Injury.Frontiers in cellular neuroscience · 2021Review
- Ampakine pretreatment enables a single brief hypoxic episode to evoke phrenic motor facilitation.Journal of neurophysiology · 2020Article
- Longitudinal effect of nocturnal R-R intervals changes on cardiovascular outcome in a community-based cohort.BMJ open · 2019Article
- Impact Of Spinal Cord Injury On Sleep: Current Perspectives.Nature and science of sleep · 2019Article
- Pharmacological modulation of hypoxia-induced respiratory neuroplasticity.Respiratory physiology & neurobiology · 2018Review
- Sleep Disordered Breathing and Spinal Cord Injury: Challenges and Opportunities.Current sleep medicine reports · 2017Article
- Ampakine CX717 potentiates intermittent hypoxia-induced hypoglossal long-term facilitation.Journal of neurophysiology · 2016Article
- Spinal cord injury is associated with enhanced peripheral chemoreflex sensitivity.Physiological reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
Abstract
Cardiorespiratory plasticity induced by acute intermittent hypoxia (AIH) may contribute to recovery following spinal cord injury (SCI). We hypothesized that patients with cervical SCI would demonstrate higher minute ventilation (V̇e) following AIH compared with subjects with thoracic SCI and able-bodied subjects who served as controls. Twenty-four volunteers (8 with cervical SCI, 8 with thoracic SCI, and 8 able-bodied) underwent an AIH protocol during wakefulness. Each subject experienced 15 episodes of isocapnic hypoxia using mixed gases of 100% nitrogen (N2), 8% O2, and 40% CO2 to achieve oxygen saturation ≤90% followed by room air (RA). Measurements were obtained before, during, and 40 min after AIH to obtain ventilation and heart rate variability data [R-R interval (RRI) and low-frequency/high-frequency power (LF/HF)]. AIH results were compared with those of sham studies conducted in RA during the same time period. Individuals with cervical SCI had higher V̇e after AIH compared with able-bodied controls (117.9 ± 23.2% vs. 97.9 ± 11.2%, P < 0.05). RRI decreased during hypoxia in all individuals (those with cervical SCI, from 1,009.3 ± 65.0 ms to 750.2 ± 65.0 ms; those with thoracic SCI, from 945.2 ± 65.0 ms to 674.9 ± 65.0 ms; and those who were able-bodied, from 949 ± 75.0 to 682.2 ± 69.5 ms; P < 0.05). LH/HF increased during recovery in individuals with thoracic SCI and those who were able-bodied (0.54 ± 0.22 vs. 1.34 ± 0.22 and 0.67 ± 0.23 vs. 1.82 ± 0.23, respectively; P < 0.05) but remained unchanged in the group with cervical SCI. Our conclusion is that patients with cervical SCI demonstrate ventilatory long-term facilitation following AIH compared with able-bodied controls. Heart rate responses to hypoxia are acutely present in patients with cervical SCI but are absent during posthypoxic recovery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.