ArticleScientific reports2015
Identification and characterization of the chromosomal yefM-yoeB toxin-antitoxin system of Streptococcus suis.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 45 citations in OpenAlex.
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- Beyond AMR and virulence databases: genome wide associations of closely relatedFrontiers in microbiology · 2026Article
- Functional analysis of the type II toxin-antitoxin system ParDE in Streptococcus suis serotype 2.BMC veterinary research · 2025Article
- Orphan response regulator CovR plays positive regulative functions in the survivability and pathogenicity of Streptococcus suis serotype 2 isolated from a pig.BMC veterinary research · 2023Article
- TheMicrobiology spectrum · 2023Article
- Toxin-antitoxin systems in pathogenic3 Biotech · 2022Review
- TroR Negatively Regulates the TroABCD System and Is Required for Resistance to Metal Toxicity and Virulence in Streptococcus suis.Applied and environmental microbiology · 2021Article
- A Markerless Gene Deletion System inMicroorganisms · 2021Article
- Genomics-guided identification of a conserved CptBA-like toxin-antitoxin system inJournal of advanced research · 2021Article
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- An Auto-Regulating Type II Toxin-Antitoxin System Modulates Drug Resistance and Virulence inFrontiers in microbiology · 2021Article
- Identifying a Molecular Mechanism That Imparts Species-Specific Toxicity to YoeB Toxins.Frontiers in microbiology · 2020Article
- Characterization of Two Toxin-Antitoxin Systems in Deep-SeaMarine drugs · 2019Article
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- Fisetin LowersFrontiers in microbiology · 2018Article
- Contribution of NADH oxidase to oxidative stress tolerance and virulence of Streptococcus suis serotype 2.Virulence · 2017Article
- Complete genome sequence of a commensal bacterium,Gut pathogens · 2017Article
- Identification and characterization of chromosomal relBE toxin-antitoxin locus in Streptomyces cattleya DSM46488.Scientific reports · 2016Article
- Keeping the Wolves at Bay: Antitoxins of Prokaryotic Type II Toxin-Antitoxin Systems.Frontiers in molecular biosciences · 2016Review
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Toxin-antitoxin (TA) systems are widely prevalent in the genomes of bacteria and archaea. These modules have been identified in Escherichia coli and various other bacteria. However, their presence in the genome of Streptococcus suis, an important zoonotic pathogen, has received little attention. In this study, we describe the identification and characterization of a type II TA system, comprising the chromosomal yefM-yoeB locus of S. suis. The yefM-yoeB locus is present in the genome of most serotypes of S. suis. Overproduction of S. suis YoeB toxin inhibited the growth of E. coli, and the toxicity of S. suis YoeB could be alleviated by the antitoxin YefM from S. suis and Streptococcus pneumoniae, but not by E. coli YefM. More importantly, introduction of the S. suis yefM-yoeB system into E. coli could affect cell growth. In a murine infection model, deletion of the yefM-yoeB locus had no effect on the virulence of S. suis serotype 2. Collectively, our data suggested that the yefM-yoeB locus of S. suis is an active TA system without the involvement of virulence.
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