Evidence map›Paper›PMID 26272269›Full record

ArticleJournal of the International Neuropsychological Society : JINS2015

Relationship between Insulin-Resistance Processing Speed and Specific Executive Function Profiles in Neurologically Intact Older Adults.

Darvis T Frazier, Brianne M Bettcher, Shubir Dutt, Nihar Patel, Dan Mungas, Joshua Miller, Ralph Green, Joel H Kramer

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the International Neuropsychological Society : JINS, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Differences between young and older adults in unity and diversity of executive functions.Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition · 2021
    Article
  9. Article
  10. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Darvis T Frazier1Memory and Aging Center,University of California,San Francisco,San Francisco,California.
Brianne M Bettcher1Memory and Aging Center,University of California,San Francisco,San Francisco,California.
Shubir Dutt1Memory and Aging Center,University of California,San Francisco,San Francisco,California.
Nihar Patel1Memory and Aging Center,University of California,San Francisco,San Francisco,California.
Dan Mungas3Department of Neurology,School of Medicine,University of California,Davis,Davis,California.
Joshua Miller4Department of Pathology and Laboratory Medicine,University of California,Davis,Davis,California.
Ralph Green4Department of Pathology and Laboratory Medicine,University of California,Davis,Davis,California.
Joel H Kramer1Memory and Aging Center,University of California,San Francisco,San Francisco,California.
University Memory and Aging Center · USUniversity of California, Davis · USUniversity of California, San Francisco · US

Funding

Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Cognitive and Neural Correlates of Inflammation in Healthy Older AdultsK23AG042492 · NIA · UNIVERSITY OF COLORADO DENVER · PI BETTCHER, BRIANNE MAGOUIRK · 2012 to 2016
$716k
NIA NIH HHS AG032289-05NIA NIH HHS K23 AG042492NIA NIH HHS R01 AG032289NIA NIH HHS RF1 AG032289
6 · The paper itself

Abstract

This study investigated the relationship between insulin-resistance and constituent components of executive function in a sample of neurologically intact older adult subjects using the homeostasis model assessment (HOMA-IR) and latent factors of working memory, cognitive control and processing speed derived from confirmatory factor analysis. Low-density lipoprotein (LDL), mean arterial pressure (MAP), along with body mass index (BMI) and white matter hypointensity (WMH) were used to control for vascular risk factors, adiposity and cerebrovascular injury. The study included 119 elderly subjects recruited from the University of California, San Francisco Memory and Aging Center. Subjects underwent neuropsychological assessment, fasting blood draw and brain magnetic resonance imaging (MRI). Partial correlations and linear regression models were used to examine the HOMA-IR-executive function relationship. Pearson correlation adjusting for age showed a significant relationship between HOMA-IR and working memory (rp = -.18; p = .047), a trend with cognitive control (rp = -.17; p = .068), and no relationship with processing speed (rp = .013; p = .892). Linear regression models adjusting for demographic factors (age, education, and gender), LDL, MAP, BMI, and WMH indicated that HOMA-IR was negatively associated with cognitive control (r = -.256; p = .026) and working memory (r = -.234; p = .054). These results suggest a greater level of peripheral insulin-resistance is associated with decreased cognitive control and working memory. After controlling for demographic factors, vascular risk, adiposity and cerebrovascular injury, HOMA-IR remained significantly associated with cognitive control, with working memory showing a trend. These findings substantiate the insulin-resistance-executive function hypothesis and suggest a complex interaction, demonstrated by the differential impact of insulin-resistance on processing speed and specific aspects of executive function.

Indexed as

AgedAged, 80 and overAgingBlood GlucoseBlood PressureBrainExecutive FunctionFastingFemaleHumansInsulin ResistanceJudgmentLipoproteins, LDLMagnetic Resonance ImagingMaleMemory, Short-TermBlood GlucoseLipoproteins, LDLCognitive controlConfirmatory factor analysisExecutive functionHomeostatic model assessmentInsulin-resistanceProcessing speedWhite matter hypointensityWorking memory

Identifiers

PMID26272269
PMCPMC4764989
OpenAlexW2157743397

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.