Evidence map›Paper›PMID 26272057›Full record

ArticleClinical rheumatology2016

The prevalence of severe fatigue in rheumatic diseases: an international study.

Cécile L Overman, Marianne B Kool, José A P Da Silva, Rinie Geenen

2 registry-linked trialsOpen access · hybridAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 106 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
106citing papers in PubMed, 9 pooled it
6.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05257174 naunknown statusnot on this mapstarted 2022, after this paper: background citation

A Randomized, Double-blind, Placebo-controlled Study to Evaluate the Effects of Jing Si Herbal Tea Liquid Packets on Fatigue in Patients With Inflammatory Arthritis

TypeinterventionalSponsorBuddhist Tzu Chi General HospitalRan2022 to 2024Enrolled150ConditionsArthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic ArthritisArmsJing Si Herbal Tea LIQUID PACKETS, Placebo
NCT06308770 narecruitingnot on this mapstarted 2024, after this paper: background citation

Fatigue in Lupus Intervention Programmes (FLIP): A Randomised Controlled Trial Investigating the Effectiveness of Fatigue Management in Systemic Lupus Erythematosus

TypeinterventionalSponsorUniversity of EdinburghRan2024 to 2027Enrolled90ConditionsSystemic Lupus ErythematosusArmsStandard Care, 4 week FMP, 7 week FMP
3 · Its place in the literature

Who cites it

106 citing papers in PubMed, 9 syntheses or guidelines pooled it, 226 citations in OpenAlex.

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46 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Cécile L OvermanDepartment of Clinical and Health Psychology, Utrecht University, PO Box 80.140, 3508 TC, Utrecht, The Netherlands. C.L.Overman@uu.nl.
Marianne B KoolDepartment of Clinical and Health Psychology, Utrecht University, PO Box 80.140, 3508 TC, Utrecht, The Netherlands.
José A P Da SilvaDepartment of Rheumatology, Hospitais da Universidade de Coimbra, 3000-075, Coimbra, Portugal.
Rinie GeenenDepartment of Clinical and Health Psychology, Utrecht University, PO Box 80.140, 3508 TC, Utrecht, The Netherlands.
Hospitais da Universidade de Coimbra · PTUniversity Medical Center Utrecht · NLUtrecht University · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Fatigue is a common, disabling, and difficult-to-manage problem in rheumatic diseases. Prevalence estimates of fatigue within rheumatic diseases vary considerably. Data on the prevalence of severe fatigue across multiple rheumatic diseases using a similar instrument is missing. Our aim was to provide an overview of the prevalence of severe fatigue across a broad range of rheumatic diseases and to examine its association with clinical and demographic variables. Online questionnaires were filled out by an international sample of 6120 patients (88 % female, mean age 47) encompassing 30 different rheumatic diseases. Fatigue was measured with the RAND(SF)-36 Vitality scale. A score of ≤35 was taken as representing severe fatigue (90 % sensitivity and 81 % specificity for chronic fatigue syndrome). Severe fatigue was present in 41 to 57 % of patients with a single inflammatory rheumatic disease such as rheumatoid arthritis, systemic lupus erythematosus, ankylosing spondylitis, Sjögren's syndrome, psoriatic arthritis, and scleroderma. Severe fatigue was least prevalent in patients with osteoarthritis (35 %) and most prevalent in patients with fibromyalgia (82 %). In logistic regression analysis, severe fatigue was associated with having fibromyalgia, having multiple rheumatic diseases without fibromyalgia, younger age, lower education, and language (French: highest prevalence; Dutch: lowest prevalence). In conclusion, one out of every two patients with a rheumatic disease is severely fatigued. As severe fatigue is detrimental to the patient, the near environment, and society at large, unraveling the underlying mechanisms of fatigue and developing optimal treatment should be top priorities in rheumatologic research and practice.

Indexed as

AdultFatigueFemaleHumansMaleMiddle AgedPrevalenceRheumatic DiseasesSurveys and QuestionnairesFatigueFibromyalgiaOsteoarthritisRheumatic diseasesRheumatoid arthritisVitality

Identifiers

PMID26272057
PMCPMC4752960
OpenAlexW1786220065

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.