ArticleMalaria journal2015
Unravelling the patterns of host immune responses in Plasmodium vivax malaria and dengue co-infection.
Article in Malaria journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 5 of them syntheses that pooled it.
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Who cites it
21 citing papers in PubMed, 5 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Worldwide distribution, symptoms and diagnosis of the coinfections between malaria and arboviral diseases: a systematic review.Memorias do Instituto Oswaldo Cruz · 2024Pooled it
- Interleukin-5 levels in relation to malaria severity: a systematic review.Malaria journal · 2023Pooled it
- Distinct cytokine profiles in malaria coinfections: A systematic review.PLoS neglected tropical diseases · 2023Pooled it
- Prevalence and laboratory analysis of malaria and dengue co-infection: a systematic review and meta-analysis.BMC public health · 2019Pooled it
- Global prevalence and distribution of coinfection of malaria, dengue and chikungunya: a systematic review.BMC public health · 2018Pooled it
- Vitamin D, D-dimer, Interferon γ, and sCD14 Levels are Independently Associated with Immune Reconstitution Inflammatory Syndrome: A Prospective, International Study.EBioMedicine · 2016Trial
- Severe Dengue and Dengue-Malaria Coinfection: A Case Series from a Referral Hospital in Montería, Colombia.Clinics and practice · 2026Article
- Coinfection of Malaria and Dengue Fever in Patients With Acute Undifferentiated Febrile Illnesses in Ghana: A Narrative Review.BioMed research international · 2026Review
- Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission.Nature communications · 2025Article
- Article
- The Role of Growth Factors in the Pathogenesis of Dengue: A Scoping Review.Pathogens (Basel, Switzerland) · 2022Article
- Uncovering the Burden of Dengue in Africa: Considerations on Magnitude, Misdiagnosis, and Ancestry.Viruses · 2022Review
- Micro-Raman spectroscopy study of optically trapped erythrocytes in malaria, dengue and leptospirosis infections.Frontiers in medicine · 2022Article
- Host Blood Gene Signatures Can Detect the Progression to Severe and Cerebral Malaria.Frontiers in cellular and infection microbiology · 2021Article
- A clinical report on mixed infection of malaria, dengue and chikungunya from New Delhi, India.Virusdisease · 2017Article
- The dangers of accepting a single diagnosis: case report of concurrent Plasmodium knowlesi malaria and dengue infection.Malaria journal · 2017Article
- Early treatment failure in concurrent dengue and mixed malaria species infection with suspected resistance to artemisinin combination therapy from a tertiary care center in Delhi: a case report.International medical case reports journal · 2017Article
- What Is Known about the Immune Response Induced byFrontiers in immunology · 2017Review
- Genome-wide association studies of immune, disease and production traits in indigenous chicken ecotypes.Genetics, selection, evolution : GSE · 2016Article
- Circulating Biomarkers of Immune Activation, Oxidative Stress and Inflammation Characterize Severe Canine Visceral Leishmaniasis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundConcurrent malaria and dengue infection is frequently diagnosed in endemic countries, but its immunopathology remains largely unknown. In the present study, a large panel of cytokines/chemokines and clinical laboratory markers were measured in patients with Plasmodium vivax and dengue co-infection as well as in individuals with malaria or dengue mono-infections in order to identify biosignatures of each clinical condition.
methodsIndividuals from the Brazilian Amazon were recruited between 2009 and 2013 and classified in three groups: vivax malaria (n = 52), dengue (n = 30) and vivax malaria and dengue co-infection (n = 30). P. vivax malaria was diagnosed by thick blood smear and confirmed by PCR; dengue cases were detected by IgM ELISA or NS1 protein. The plasma levels of cytokines and chemokines were determined by multiplex assay.
resultsIndividuals with malaria and dengue co-infection displayed lower levels of platelets and haemoglobin than those with malaria or dengue mono-infections (p = 0.0047 and p = 0.0001, respectively). The group of individuals co-infected exhibited the highest median concentrations of IFN-γ, IL-6, CCL4 than the mono-infected groups. Network analyses of plasma cytokines/chemokines revealed that malaria and dengue co-infection exhibits a distinct immune profile with critical roles for TNF, IL-6 and IFN-γ. Further, parasitaemia levels displayed positive significant interactions with IL-6, CCL4 and IL-10 in the group of patients co-infected with malaria and dengue. No differences were observed in distribution of dengue virus serotypes and Plasmodium parasitaemia levels between the groups.
conclusionsThe findings described here identify unique patterns of circulating immunological markers in cases of malaria and dengue co-infection and provide insights on the immunopathology of this co-morbid condition.
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