Trial reportScientific reports2015
Improved human visuomotor performance and pupil constriction after choline supplementation in a placebo-controlled double-blind study.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 42 citations in OpenAlex.
- Depressive Symptoms Associated with Decreased Choline Intake in Lactating Mothers of Preterm Infants.Nutrients · 2026Article
- Ginkgo Biloba as a niche theme cognitive enhancer agent, 1420 dokumen of Scopus database. A bibliometric study from 1988 to 2024.F1000Research · 2025Article
- The interaction effect of metals exposure and dietary habit on cognitive function in Chinese older adult cohort.The journal of nutrition, health & aging · 2024Article
- Higher intake of certain nutrients among older adults is associated with better cognitive function: an analysis of NHANES 2011-2014.BMC nutrition · 2023Article
- Assessment of Anti-Alzheimer Pursuit of Jambolan Fruit Extract and/or Choline against AlClToxics · 2023Article
- Association between choline supplementation and Alzheimer's disease risk: a systematic review protocol.Frontiers in aging neuroscience · 2023Article
- Choline supplements: An update.Frontiers in endocrinology · 2023Review
- The impact of nutrition on visual cognitive performance in the nutrition, vision, and cognition in sport study.Frontiers in nutrition · 2023Article
- Effect of Zanthoxylum bungeanum essential oil on rumen enzyme activity, microbiome, and metabolites in lambs.PloS one · 2022Article
- Egg intake moderates the rate of memory decline in healthy older adults.Journal of nutritional science · 2021Article
- Pupillometric investigation into the speed-accuracy trade-off in a visuo-motor aiming task.Psychophysiology · 2020Article
- Article
- Review
- Betaine and Choline Improve Lipid Homeostasis in Obesity by Participation in Mitochondrial Oxidative Demethylation.Frontiers in nutrition · 2018Article
- Acceptability, Safety, and Efficacy of Oral Administration of Extracts of Black or Red Maca (Lepidium meyenii) in Adult Human Subjects: A Randomized, Double-Blind, Placebo-Controlled Study.Pharmaceuticals (Basel, Switzerland) · 2016Article
- No Acute Effects of Choline Bitartrate Food Supplements on Memory in Healthy, Young, Human Adults.PloS one · 2016Article
- Mobility and Upright Posture Are Associated with Different Aspects of Cognition in Older Adults.Frontiers in aging neuroscience · 2016Article
- Inferior Prefrontal Cortex Mediates the Relationship between Phosphatidylcholine and Executive Functions in Healthy, Older Adults.Frontiers in aging neuroscience · 2016Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Only few nutrients are known to enhance cognition. Here we explore whether visuomotor performance can be improved through the intake of the nutrient choline, an essential chemical compound in a vertebrate's diet. Choline is abundant in for example eggs and shrimps and many animal studies suggest that it serves as a cognitive enhancer. As choline is important for the communication between motor neurons and the control of skeletal muscles, we assumed that choline supplementation may have positive effects on action coordination in humans. A group of twenty-eight individuals ingested two grams of choline bitartrate or a placebo in two separate sessions. Seventy minutes post ingestion, participants performed a visuomotor aiming task in which they had to rapidly hit the centers of targets. Results showed that participants hit targets more centrally after choline supplementation. Pupil size (a cognition-sensitive biomarker) also significantly decreased after choline intake and correlated positively with the hit distance to the targets and the number of target misses, and negatively with reaction times. These findings point to a choline-induced bias towards action precision in the trade-off between speed and accuracy. The changes in pupil size suggest that choline uptake alters cholinergic functions in the nervous system.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.