Evidence map›Paper›PMID 26271815›Full record

Trial reportAIDS and behavior2015

Effectiveness of peer support on care engagement and preventive care intervention utilization among pre-antiretroviral therapy, HIV-infected adults in Rakai, Uganda: a randomized trial.

Larry W Chang, Gertrude Nakigozi, Veena G Billioux, Ronald H Gray, David Serwadda, Thomas C Quinn, Maria J Wawer, Robert C Bollinger, Steven J Reynolds

Abstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  11. Psychosocial Phenotype and Risky Sexual Behavior Among People Living with HIV in Changsha: A Latent Profile Analysis.International journal of sexual health : official journal of the World Association for Sexual Health · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Larry W ChangDivision of Infectious Diseases, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Suite 216, Baltimore, MD, 21205, USA. larrywillchang@gmail.com.
Gertrude NakigoziRakai Health Sciences Program, Rakai, Uganda.
Veena G BilliouxDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Ronald H GrayDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
David SerwaddaRakai Health Sciences Program, Rakai, Uganda.
Thomas C QuinnDivision of Infectious Diseases, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Suite 216, Baltimore, MD, 21205, USA.
Maria J WawerDepartment of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA.
Robert C BollingerDivision of Infectious Diseases, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Suite 216, Baltimore, MD, 21205, USA.
Steven J ReynoldsDivision of Infectious Diseases, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Suite 216, Baltimore, MD, 21205, USA.

Funding

Vaccine Response and Immunotherapeutics SWGP30AI094189 · NIAID · JOHNS HOPKINS UNIVERSITY · PI Richard E. Chaisson · 2012 to 2026
$67.0M
International Center for Excellence in Research (ICER) in Uganda: Impact of ARVsZIAAI001040 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REYNOLDS, STEVEN · 2009 to 2025
$23.5M
International Studies of the Acquired Immune Deficiency Syndrome (AIDS)ZIAAI000361 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI REDD, ANDREW · 2009 to 2025
$15.8M
Peer health workers: Impact on retention, care and secondary prevention of PLHIVK23MH086338 · NIMH · JOHNS HOPKINS UNIVERSITY · PI CHANG, LARRY WILLIAM · 2010 to 2014
$914k
Intramural NIH HHSNIAID NIH HHS P30 AI094189NIAID NIH HHS P30AI094189NIMH NIH HHS K23 MH086338NIMH NIH HHS K23MH086338
6 · The paper itself

Abstract

442 pre-ART, HIV-infected adults were randomized to peer support consisting of structured home visits to promote clinic attendance and preventive care intervention use or standard of care. At baseline, 62 % reported previously visiting an HIV clinic, 45 % reported taking cotrimoxazole prophylaxis, and 31 % were "care-naïve" (no previous clinic visit and not on cotrimoxazole). After 1 year, intervention participants were more likely to report being in care (92 vs 84 %; PRR 1.09, p = 0.039), on cotrimoxazole (89 vs 81 %; PRR 1.10, p = 0.047), and safe water vessel adherence (23 vs 14 %; PRR 1.64, p = 0.024). The effect was observed only among care-naïve participants (n = 139) with 83 % intervention versus 56 % controls reporting being in HIV care (PRR 1.47, p = 0.006), 78 versus 58 % on cotrimoxazole (PRR 1.35, p = 0.04), and 20 versus 4 % safe water vessel adherence (PRR 5.78, p = 0.017). Peer support may be an effective intervention to facilitate pre-ART care compliance in this important population.

Indexed as

Peer GroupSocial SupportAdultAmbulatory CareAnti-HIV AgentsFollow-Up StudiesHIV InfectionsHouse CallsHumansKaplan-Meier EstimateMaleOffice VisitsOutcome and Process Assessment, Health CarePatient Acceptance of Health CarePreventive Health ServicesSocioeconomic FactorsAnti-HIV AgentsImplementation scienceLinkagePeer supportRandomized controlled trialUganda

Identifiers

PMID26271815
PMCPMC4567424

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.