Evidence map›Paper›PMID 26271509›Full record

ArticleProtein & cell2015

Direct intercellular communications dominate the interaction between adipose-derived MSCs and myofibroblasts against cardiac fibrosis.

Xiaokang Li, Hui Zhao, Chunxiao Qi, Yang Zeng, Feng Xu, Yanan Du

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Protein & cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Xiaokang LiDepartment of Biomedical Engineering, School of Medicine, Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases, Tsinghua University, Beijing, 100084, China.
Hui ZhaoDepartment of Biomedical Engineering, School of Medicine, Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases, Tsinghua University, Beijing, 100084, China.
Chunxiao QiDepartment of Biomedical Engineering, School of Medicine, Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases, Tsinghua University, Beijing, 100084, China.
Yang ZengDepartment of Biomedical Engineering, School of Medicine, Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases, Tsinghua University, Beijing, 100084, China.
Feng XuMOE Key Laboratory of Biomedical Information Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, 710049, China.
Yanan DuDepartment of Biomedical Engineering, School of Medicine, Collaborative Innovation Center for Diagnosis and Treament of Infectious Diseases, Tsinghua University, Beijing, 100084, China. duyanan@tsinghua.edu.cn.
Tsinghua University · CNXi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The onset of cardiac fibrosis post myocardial infarction greatly impairs the function of heart. Recent advances of cell transplantation showed great benefits to restore myocardial function, among which the mesenchymal stem cells (MSCs) has gained much attention. However, the underlying cellular mechanisms of MSC therapy are still not fully understood. Although paracrine effects of MSCs on residual cardiomyocytes have been discussed, the amelioration of fibrosis was rarely studied as the hostile environment cannot support the survival of most cell populations and impairs the diffusion of soluble factors. Here in order to decipher the potential mechanism of MSC therapy for cardiac fibrosis, we investigated the interplay between MSCs and cardiac myofibroblasts (mFBs) using interactive co-culture method, with comparison to paracrine approaches, namely treatment by MSC conditioned medium and gap co-culture method. Various fibrotic features of mFBs were analyzed and the most prominent anti-fibrosis effects were always obtained using direct co-culture that allowed cell-to-cell contacts. Hepatocyte growth factor (HGF), a well-known anti-fibrosis factor, was demonstrated to be a major contributor for MSCs' anti-fibrosis function. Moreover, physical contacts and tube-like structures between MSCs and mFBs were observed by live cell imaging and TEM which demonstrate the direct cellular interactions.

Indexed as

Cell CommunicationAdipose TissueAnimalsCell DifferentiationCell MovementCell SurvivalCoculture TechniquesFibrosisMaleMesenchymal Stem CellsMyocardiumMyofibroblastsPhenotypeRatsRats, Sprague-Dawleyadipose-derived mesenchymal stem cellsanti-fibrosiscardiac fibrosiscell-to-cell contactmyofibroblastsstem cell therapy

Identifiers

PMID26271509
PMCPMC4598323
OpenAlexW2402796135

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.