ArticlePain medicine (Malden, Mass.)2016
Familial Contributions to Self-Reported Sleep and Pain in Female Twins.
Article in Pain medicine (Malden, Mass.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 3 citations in OpenAlex.
- Polygenic evidence and overlapped brain functional connectivities for the association between chronic pain and sleep disturbance.Translational psychiatry · 2020Article
- Genetic and Environmental Influences on Sleep, Pain, and Depression Symptoms in a Community Sample of Twins.Psychosomatic medicineArticle
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveThe relationship between sleep quality and pain has been studied in populations with chronic pain and in nonclinical populations using experimental paradigms. Little is known about the familial contributions to this relationship. This study examines self-reported sleep quality and pain in a nonclinical sample and to explore familial (i.e., shared genetic and common family environment) confounding in those relationships.
designCross-sectional. SUBJECTS: Ninety nine community-based female twin pairs (N = 198) with a mean age of 29 years; 72% monozygotic.
methodsThe short form McGill Pain Questionnaire (McGill), a visual analog scale (VAS), a body map, and the Pittsburgh Sleep Quality Index (PSQI) measured self-reported pain and sleep quality. Mixed model regression adjusted for age was used to examine relationships between the pain indices and PSQI in overall and within-pair models.
resultsHigher PSQI total scores were significantly associated with higher scores across the McGill sensory (B = 0.37, p < 0.001), affective (B = 0.16, p < 0.001), total scores (B = 0.54, p < 0.001), the VAS (B = 2.41, p < 0.001), and number of sites with any pain on the body map (B = 0.42, p = 0.001). All of these associations were diminished and rendered nonsignificant in within-pair analyses that accounted for genetic and familial factors (all p's ≥ 0.01; Bonferroni α = 0.01).
conclusionsThese findings support an association between poor sleep quality and pain and suggest that this relationship may be confounded by shared genetic and environmental factors, which could elucidate biological mechanisms that underlie the development and maintenance of pain and sleep problems.
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