Evidence map›Paper›PMID 26271459›Full record

ReviewJournal of cardiovascular translational research2015

A Guide for a Cardiovascular Genomics Biorepository: the CATHGEN Experience.

William E Kraus, Christopher B Granger, Michael H Sketch, Mark P Donahue, Geoffrey S Ginsburg, Elizabeth R Hauser, Carol Haynes, L Kristin Newby, Melissa Hurdle, Z Elaine Dowdy and 1 more

Open access · greenAbstract readReview
In one paragraph

Review in Journal of cardiovascular translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 3 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 3 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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  20. Sex-dimorphic gene effects on survival outcomes in people with coronary artery disease.American heart journal plus : cardiology research and practice · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

William E KrausDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA. william.kraus@duke.edu.ORCID http://orcid.org/0000-0003-1930-9684
Christopher B GrangerDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Michael H SketchDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Mark P DonahueDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Geoffrey S GinsburgDuke Center for Applied Genomics and Precision Medicine, Duke University, Durham, NC, 27710, USA.
Elizabeth R HauserDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Carol HaynesDuke Molecular Physiology Institute, School of Medicine, Duke University, 300 N. Duke Street, Durham, NC, 27710, USA.
L Kristin NewbyDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Melissa HurdleDuke Molecular Physiology Institute, School of Medicine, Duke University, 300 N. Duke Street, Durham, NC, 27710, USA.
Z Elaine DowdyDuke Molecular Physiology Institute, School of Medicine, Duke University, 300 N. Duke Street, Durham, NC, 27710, USA.
Svati H ShahDivision of Cardiology, Department of Medicine, School of Medicine, Duke University, Durham, NC, 27710, USA.
Duke University · US

Funding

Pilot Project for the DTMI CRA ProgramUL1RR024128 · NCRR · DUKE UNIVERSITY · PI CALIFF, ROBERT M · 2006 to 2010
$48.1M
Metabolomic Quantitative Trait Locus (mQTL) Genetic Mapping in Human CVDR01HL095987 · NHLBI · DUKE UNIVERSITY · PI SHAH, SVATI H. · 2009 to 2013
$3.4M
Genetic Mediators of Metabolic Cardiovascular Disease RiskRC2HL101621 · NHLBI · DUKE UNIVERSITY · PI KRAUS, WILLIAM E · 2009 to 2010
$3.2M
NCRR NIH HHS 1UL1RR024128NCRR NIH HHS UL1 RR024128NHLBI NIH HHS HL095987NHLBI NIH HHS HL101621NHLBI NIH HHS R01 HL095987NHLBI NIH HHS RC2 HL101621
6 · The paper itself

Abstract

The CATHeterization GENetics (CATHGEN) biorepository was assembled in four phases. First, project start-up began in 2000. Second, between 2001 and 2010, we collected clinical data and biological samples from 9334 individuals undergoing cardiac catheterization. Samples were matched at the individual level to clinical data collected at the time of catheterization and stored in the Duke Databank for Cardiovascular Diseases (DDCD). Clinical data included the following: subject demographics (birth date, race, gender, etc.); cardiometabolic history including symptoms; coronary anatomy and cardiac function at catheterization; and fasting chemistry data. Third, as part of the DDCD regular follow-up protocol, yearly evaluations included interim information: vital status (verified via National Death Index search and supplemented by Social Security Death Index search), myocardial infarction (MI), stroke, rehospitalization, coronary revascularization procedures, medication use, and lifestyle habits including smoking. Fourth, samples were used to generate molecular data. CATHGEN offers the opportunity to discover biomarkers and explore mechanisms of cardiovascular disease.

Indexed as

Biological Specimen BanksDatabases, GeneticCardiovascular DiseasesGene-Environment InteractionGene Expression ProfilingGenetic Association StudiesGenetic MarkersGenetic Predisposition to DiseaseGenetic TestingGenomicsHumansIntellectual PropertyModels, OrganizationalPhenotypePredictive Value of TestsPrognosisGenetic MarkersAir pollutionBiomarkersBiorepositoryCardiometabolic diseaseCardiovascular diseaseGeneticsGenomicsGeocodingMetabolomics

Identifiers

PMID26271459
PMCPMC4651812
OpenAlexW1129605249

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.