ArticleChest2015
Clinical Characteristics and Outcomes Are Similar in ARDS Diagnosed by Oxygen Saturation/Fio2 Ratio Compared With Pao2/Fio2 Ratio.
Article in Chest, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 170 citations in OpenAlex.
- Predictive Value of the PaOInternal medicine (Tokyo, Japan) · 2025Pooled it
- Pooled it
- Use of volume controlled vs. pressure controlled volume guaranteed ventilation in elderly patients undergoing laparoscopic surgery with laryngeal mask airway.BMC anesthesiology · 2021Trial
- Machine learning model for early prediction of acute respiratory failure in acute pancreatitis: Multicenter validation.iScience · 2026Article
- Validation of SpOAdvances in respiratory medicine · 2026Article
- Predictive Value of SpO2/RR Ratio for Short-Term Intubation and Mortality Risks in Pre-ED Patients With Acute Dyspnea Without Oxygen Therapy: A Retrospective Cohort Study.Emergency medicine international · 2026Article
- Relationship between SpOFrontiers in medicine · 2026Article
- Empirical phenotyping of joint patient-care data supports hypothesis-driven investigation of mechanical ventilation consequences.Scientific reports · 2025Article
- Developing A Data Pipeline to Quantify Ventilator Waveforms.medRxiv : the preprint server for health sciences · 2025Article
- An early predictive model for acute respiratory distress-syndrome related to pancreatitis in pregnancy: an 8-year multicenter analysis.European journal of medical research · 2025Article
- Role of Oxygen Saturation Index as a Noninvasive Surrogate Marker of Oxygenation in Intubated Critically Ill Adult Patients: A Prospective Observational Study.Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine · 2025Article
- A nomogram for individualized prediction of acute respiratory distress syndrome in patients with severe traumatic brain injury: a retrospective cohort study.BMC pulmonary medicine · 2025Article
- SpOBiomedicines · 2025Article
- Evaluating the Use of Inhaled Budesonide and Ipratropium Bromide Combination in Patients at High Risk of Acute Respiratory Distress Syndrome Development: A Randomized Controlled Trial.Pharmaceuticals (Basel, Switzerland) · 2025Article
- Limitations of SpOCritical care (London, England) · 2025Observational
- Respiratory physiological changes post initiation of neurally adjusted ventilatory assist in preterm infants with evolving or established bronchopulmonary dysplasia.European journal of pediatrics · 2025Article
- A modified screening protocol for ARDS in patients with respiratory support based on SpOJournal of intensive medicine · 2025Article
- Machine and Deep Learning Models for Hypoxemia Severity Triage in CBRNE Emergencies.Diagnostics (Basel, Switzerland) · 2024Article
- Novel Oxygenation and Saturation Indices for Mortality Prediction in COVID-19 ARDS Patients: The Impact of Driving Pressure and Mechanical Power.Journal of intensive care medicine · 2024Article
- Association between prehospital ROX index with 30-day mortality among septic shock.European journal of medical research · 2024Article
29 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundOxygen saturation as measured by pulse oximetry/Fio2 (SF) ratio is highly correlated with the Pao2/Fio2 (PF) ratio in patients with ARDS. However, it remains uncertain whether SF ratio can be substituted for PF ratio for diagnosis of ARDS and whether SF ratio might identify patients who are systemically different from patients diagnosed by PF ratio.
methodsWe conducted a secondary analysis of a large observational prospective cohort study. Patients were eligible if they were admitted to the medical ICU and fulfilled the Berlin definition of ARDS with hypoxemia criteria using either the standard PF threshold (PF ratio ≤ 300) or a previously published SF threshold (SF ratio ≤ 315).
resultsOf 362 patients with ARDS, 238 (66%) received a diagnosis by PF ratio and 124 (34%) by SF ratio. In a small group of patients who received diagnoses of ARDS by SF ratio who had arterial blood gas measurements on the same day (n = 10), the PF ratio did not meet ARDS criteria. There were no major differences in clinical characteristics or comorbidities between groups with the exception of APACHE (Acute Physiology and Chronic Health Evaluation) II scores, which were higher in the group diagnosed by PF ratio. However, this difference was no longer apparent when arterial blood gas-dependent variables (pH, Pao2) were removed from the APACHE II score. There were also no differences in clinical outcomes including duration of mechanical ventilation (mean, 7 days in both groups; P = .25), duration of ICU stay (mean, 10 days vs 9 days in PF ratio vs SF ratio; P = .26), or hospital mortality (36% in both groups, P = .9).
conclusionsPatients with ARDS diagnosed by SF ratio have very similar clinical characteristics and outcomes compared with patients diagnosed by PF ratio. These findings suggest that SF ratio could be considered as a diagnostic tool for early enrollment into clinical trials.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.