ArticleScientific reports2015
An integrated system for identifying the hidden assassins in traditional medicines containing aristolochic acids.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
- Detection and Removal of Aristolochic Acid in Natural Plants, Pharmaceuticals, and Environmental and Biological Samples: A Review.Molecules (Basel, Switzerland) · 2023Review
- Enhanced Production of Nitrogenated Metabolites with Anticancer Potential inInternational journal of molecular sciences · 2023Article
- Insights into taxonomy and phylogenetic relationships of elevenFrontiers in plant science · 2023Article
- Aristolochic acid-associated cancers: a public health risk in need of global action.Nature reviews. Cancer · 2022Review
- A PCR-lateral flow immunochromatographic assay (PCR-LFA) for detecting Aristolochia species, the plants responsible for aristolochic acid nephropathy.Scientific reports · 2022Article
- A Review on Application of DNA Barcoding Technology for Rapid Molecular Diagnostics of Adulterants in Herbal Medicine.Drug safety · 2022Review
- Improvement in the Blood Urea Nitrogen and Serum Creatinine Using New Cultivation ofEvidence-based complementary and alternative medicine : eCAM · 2022Article
- Licorice Germplasm Resources Identification Using DNA Barcodes Inner-Variants.Plants (Basel, Switzerland) · 2021Article
- Applied Barcoding: The Practicalities of DNA Testing for Herbals.Plants (Basel, Switzerland) · 2020Article
- Authentication ofFoods (Basel, Switzerland) · 2020Article
- Species Quantification in Complex Herbal Formulas-Vector Control Quantitative Analysis as a New Method.Frontiers in pharmacology · 2020Article
- Article
- Complete Chloroplast Genomes and Comparative Analysis of Sequences Evolution among SevenInternational journal of molecular sciences · 2019Article
- Biomonitoring for traditional herbal medicinal products using DNA metabarcoding and single molecule, real-time sequencing.Acta pharmaceutica Sinica. B · 2018Article
- Article
- Using SSR-HRM to Identify Closely Related Species in Herbal Medicine Products: A Case Study on Licorice.Frontiers in pharmacology · 2018Article
- Identifying the Species of Seeds in Traditional Chinese Medicine Using DNA Barcoding.Frontiers in pharmacology · 2018Article
- Sequence-Specific Detection ofFrontiers in plant science · 2018Article
- Establishment of the most comprehensive ITS2 barcode database to date of the traditional medicinal plant Rhodiola (Crassulacaee).Scientific reports · 2017Article
- Barcode ITS2: a useful tool for identifying Trachelospermum jasminoides and a good monitor for medicine market.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
12 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Traditional herbal medicines adulterated and contaminated with plant materials from the Aristolochiaceae family, which contain aristolochic acids (AAs), cause aristolochic acid nephropathy. Approximately 256 traditional Chinese patent medicines, containing Aristolochiaceous materials, are still being sold in Chinese markets today. In order to protect consumers from health risks due to AAs, the hidden assassins, efficient methods to differentiate Aristolochiaceous herbs from their putative substitutes need to be established. In this study, 158 Aristolochiaceous samples representing 46 species and four genera as well as 131 non-Aristolochiaceous samples representing 33 species, 20 genera and 12 families were analyzed using DNA barcodes based on the ITS2 and psbA-trnH sequences. Aristolochiaceous materials and their non-Aristolochiaceous substitutes were successfully identified using BLAST1, the nearest distance method and the neighbor-joining (NJ) tree. In addition, based on sequence information of ITS2, we developed a Real-Time PCR assay which successfully identified herbal material from the Aristolochiaceae family. Using Ultra High Performance Liquid Chromatography-Mass Spectrometer (UHPLC-HR-MS), we demonstrated that most representatives from the Aristolochiaceae family contain toxic AAs. Therefore, integrated DNA barcodes, Real-Time PCR assays using TaqMan probes and UHPLC-HR-MS system provides an efficient and reliable authentication system to protect consumers from health risks due to the hidden assassins (AAs).
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