Evidence map›Paper›PMID 26270946›Full record

Trial reportBMJ open2015

After the diabetes care trial ends, now what? A 1-year follow-up of the RxING study.

Yazid N Al Hamarneh, Luc Sauriol, Ross T Tsuyuki

Registry-linked trialAbstract readClinical Trial
In one paragraph

Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01335763 (Pharmacist Intervention for Glycemic Control in The Community), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01335763 nacompletednot on this map

Pharmacist Intervention for Glycemic Control in The Community (The RxING Study)

TypeinterventionalSponsorUniversity of AlbertaRan2011 to 2012Enrolled100ConditionsType 2 DiabetesArmsInsulin glargine
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Follow-up in community pharmacy should be routine, not extraordinary.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
  3. Hypertension Canada's 2020 hypertension guidelines for pharmacists: An update.Canadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
  4. Real-world implementation of diabetes management by pharmacists: The RCanadian pharmacists journal : CPJ = Revue des pharmaciens du Canada : RPC
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Yazid N Al HamarnehEPICORE Centre, Department of Medicine, Faculty of medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.
Luc SauriolDepartment of Health Economics, Sanofi Canada, Laval, Quebec, Canada.
Ross T TsuyukiEPICORE Centre, Department of Medicine, Faculty of medicine and Dentistry, University of Alberta, Edmonton, Alberta, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionThere is strong evidence that pharmacist care improves patients' glycaemic control. However, the sustainability and durability of such interventions beyond the research period is not known. RxING was the first trial of pharmacist prescribing in diabetes and it showed an improvement in glycated haemoglobin (HbA1c) of 1.8% over 6 months.

objective1° objective: To evaluate glycaemic control in the RxING study patients 12 months after the end of the formal study follow-up. 2° objective: To assess the patients' risk of cardiovascular events in the next 10 years.

methodsWe contacted the participating pharmacists to check if the patients who participated in the RxING study are still taking insulin, the dose of insulin they are taking, and their HbA1c. There were no mandated follow-up visits with the pharmacist after the study completion.

resultsA total of 100 patients with poorly controlled type 2 diabetes were enrolled in the original RxING study; 93 of them completed the study, while 83 participated in the 12-month follow-up. Seventy-five patients were still taking insulin, with the average dose increasing from 31.1 units (SD 18.4) at study completion to 37.4 units (SD 30.8) (95% CI -13.3 to 0.88, p=0.085). HbA1c was reduced from 9.1% (SD 1) at baseline to 7.3% (SD 0.9) at study completion (95% CI 1.4 to 2, p <0.001), and increased to 8.1% (SD 1.3) 12 months later (95% CI -1.1 to -0.5, p <0.001 vs study completion).

conclusionsTwelve months after completing the intervention, approximately half of the glycaemic control gains were lost. This highlights the importance of structured follow-up with the pharmacist in this patient population. TRIAL REGISTRATION NUMBER: clinicaltrials.gov; Identifier: NCT01335763.

Indexed as

Medication AdherenceAgedBlood GlucoseDiabetes Mellitus, Type 2FemaleFollow-Up StudiesGlycated HemoglobinHumansInsulinMaleMiddle AgedPharmacistsBlood GlucoseGlycated HemoglobinInsulinPUBLIC HEALTH

Identifiers

PMID26270946
PMCPMC4538249

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.