ArticlePediatric research2015
Evaluation of kidney dysfunction and angiotensinogen as an early novel biomarker of intrauterine growth restricted offspring rats.
Article in Pediatric research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 18 citations in OpenAlex.
- Evaluation of kidney injury and metabolomic analysis in adulthood in a non-obese hyperglycemic female mouse model after birth with low birthweight.BMC nephrology · 2025Article
- Summary Concerning 16 Years of Research Activities in the Department of Pediatrics at Juntendo University.Juntendo medical journal · 2025Article
- [Functional MRI assessment of microstructural and perfusion changes in the kidneys of rats with intrauterine growth restriction].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2024Article
- Various Organ Damages in Rats with Fetal Growth Restriction and Their Slight Attenuation byLife (Basel, Switzerland) · 2023Article
- Site-1 Protease-Derived Soluble (Pro)Renin Receptor Contributes to Angiotensin II-Induced Hypertension in Mice.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Role of renal sympathetic nerve activity in prenatal programming of hypertension.Pediatric nephrology (Berlin, Germany) · 2018Review
- Effect of renal denervation on urine angiotensinogen excretion in prenatally programmed rats.Physiological reports · 2017Article
- Transient enalapril attenuates the reduction in glomerular filtration rate in prenatally programmed rats.Physiological reports · 2017Article
- [A preliminary study of renal function in small-for-gestational-age infants at early stage after birth].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2017Article
- Transient Exposure of Enalapril Normalizes Prenatal Programming of Hypertension and Urinary Angiotensinogen Excretion.PloS one · 2015Article
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Authors and funding
15 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFew studies have addressed the growing concerns of chronic kidney diseases in children with intrauterine growth restriction (IUGR). Therefore, the purpose of this study was to evaluate long-term kidney dysfunction and determine if urinary angiotensinogen (AGT) was suitable as a novel early biomarker for kidney dysfunction in IUGR offspring.
methodsPregnant rats underwent bilateral uterine artery ligation, and as a control group, sham surgeries were performed.
resultsThe birth weight was reduced, the urinary AGT to creatinine ratio was significantly higher at week 20, and urinary protein levels were significantly higher at week 32 in IUGR rats than in control rats. On the other hand, the histological findings at week 32 revealed long-term kidney dysfunction, more severe glomerulosclerosis, and greater glomerular diameters in IUGR rats. Moreover, AGT mRNA expression and immunohistological staining were significantly increased in IUGR rats; this suggests that the intrarenal renin-angiotensin system (RAS) contributes to renal dysfunction of IUGR offspring.
conclusionUrinary AGT elevation prior to urinary protein levels suggests that AGT is an early biomarker. At week 32, kidney dysfunction was severe in IUGR rats and intrarenal RAS appeared to be one of the causes.
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