Evidence map›Paper›PMID 26270232›Full record

ArticleBritish journal of cancer2015

Serum levels of chemokines CCL4 and CCL5 in cirrhotic patients indicate the presence of hepatocellular carcinoma.

M Sadeghi, I Lahdou, H Oweira, V Daniel, P Terness, J Schmidt, K-H Weiss, T Longerich, P Schemmer, G Opelz and 1 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in British journal of cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Nutrients Lowering Obesity-Linked Chemokines Blamable for Metastasis.International journal of molecular sciences · 2025
    Review
  4. Article
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  7. [Research Progresses on the Effects of CCL4 on Immune Escape 
in Tumor Microenvironment].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2024
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

M SadeghiDepartment of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
I LahdouDepartment of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
H OweiraDepartment of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
V DanielDepartment of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
P TernessDepartment of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
J SchmidtDepartment of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
K-H WeissDepartment of Internal Medicine IV, University of Heidelberg, Heidelberg, Germany.
T LongerichDepartment of Pathology, University of Heidelberg, Heidelberg, Germany.
P SchemmerDepartment of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
G OpelzDepartment of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany.
A MehrabiDepartment of General, Visceral and Transplant Surgery, University of Heidelberg, Heidelberg, Germany.
Heidelberg University · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMost hepatocellular carcinomas (HCCs) are diagnosed at an advanced stage. The prognostic value of serum tumour markers alpha-fetoprotein (AFP) and des-gamma-carboxy prothrombin (DCP) is limited. The aim of our study is to evaluate the diagnostic value of serum growth factors, apoptotic and inflammatory mediators of cirrhotic patients with and without HCC.

methodsSerum samples were collected from cirrhotic potential liver transplant patients (LTx) with (n=61) and without HCC (n=78) as well as from healthy controls (HCs; n=39). Serum concentrations of CRP, neopterin and IL-6 as markers of inflammation and thrombopoietin (TPO), GCSF, FGF basic and VEGF, HMGB1, CK-18 (M65) and CK18 fragment (M30) and a panel of proinflammatory chemokines (CCL2, CCL3, CCL4, CCL5, CXCL5 and IL-8) were measured. Chi square, Fisher exact, Mann-Whitney U-tests, ROC curve analysis and forward stepwise logistic regression analyses were applied.

resultsPatients with HCC had higher serum TPO and chemokines (P<0.001 for TPO, CCL4, CCL5 and CXCL5) and lower CCL2 (P=0.008) levels than cirrhotic patients without HCC. Multivariate forward stepwise regression analysis for significant parameters showed that among the studied parameters CCL4 and CCL5 (P=0.001) are diagnostic markers of HCC. Serum levels of TPO and chemokines were lower, whereas M30 was significantly higher in cirrhotic patients than in HCs.

conclusionsHigh serum levels of inflammatory chemokines such as CCL4 and CCL5 in the serum of cirrhotic patients indicate the presence of HCC.

Indexed as

AgedAutoantigensBiomarkers, TumorCarcinoma, HepatocellularCase-Control StudiesChemokine CCL4Chemokine CCL5Early Detection of CancerFemaleHumansIodide PeroxidaseIron-Binding ProteinsLiver CirrhosisLiver NeoplasmsMaleMiddle AgedAutoantigensBiomarkers, TumorCCL4 protein, humanCCL5 protein, humanChemokine CCL4Chemokine CCL5Iodide PeroxidaseIron-Binding ProteinsTPO protein, human

Identifiers

PMID26270232
PMCPMC4559820
OpenAlexW1539522283

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.