Trial reportPloS one2015
Non-Invasive Measurement of Skin Microvascular Response during Pharmacological and Physiological Provocations.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Early Detection of Taxane-Induced Neuropathy in Women With Breast Cancer
Comparison of Laser Speckle Contrast Imaging and Laser Doppler Imaging
Who cites it
24 citing papers in PubMed, 62 citations in OpenAlex.
- Trial
- Perfusion of the skin's microcirculation after cold-water immersion (10°C) and partial-body cryotherapy (-135°C).Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2019Trial
- Site-Specific Characterization and Quantification of Facial Corticosteroid Addiction Dermatitis: A Multimodal Nomogram Integrating High-Frequency Ultrasonography and Transepidermal Water Loss.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2026Article
- Rapid noncontact laser speckle imaging for perfusion-based differentiation of wound necrosis.iScience · 2026Article
- Homeostatic Responses to Subsystolic Arterial Occlusive Pressure in Glabrous and Non-Glabrous Skin Circulation.Biomedicines · 2026Article
- Article
- Advancing DIEP Flap Monitoring with Optical Imaging Techniques: A Narrative Review.Sensors (Basel, Switzerland) · 2024Review
- Short-term cutaneous vasodilatory and thermosensory effects of topical methyl salicylate.Frontiers in physiology · 2024Article
- In vivo dose-response analysis to acetylcholine: pharmacodynamic assessment by polarized reflectance spectroscopy.Scientific reports · 2022Article
- Towards Development of Specular Reflection Vascular Imaging.Sensors (Basel, Switzerland) · 2022Article
- Effects of Normal Reference Range of Phosphorus and Corresponding PTH on Endothelial Function in CKD Patients.Frontiers in medicine · 2022Article
- Wavelet analysis of laser Doppler microcirculatory signals: Current applications and limitations.Frontiers in physiology · 2022Review
- Investigation of proteins important for microcirculation using in vivo microdialysis after glucose provocation: a proteomic study.Scientific reports · 2021Observational
- Oral Glucose Load and Human Cutaneous Microcirculation: An Insight into Flowmotion Assessed by Wavelet Transform.Biology · 2021Article
- The Association between Foot and Ulcer Microcirculation Measured with Laser Speckle Contrast Imaging and Healing of Diabetic Foot Ulcers.Journal of clinical medicine · 2021Article
- Obesity-Related Inflammation and Endothelial Dysfunction in COVID-19: Impact on Disease Severity.Journal of inflammation research · 2021Review
- Semi-Automatic Tracking of Laser Speckle Contrast Images of Microcirculation in Diabetic Foot Ulcers.Diagnostics (Basel, Switzerland) · 2020Article
- Epinephrine penetrates through gingival sulcus unlike keratinized gingiva and evokes remote vasoconstriction in human.BMC oral health · 2020Article
- Clinical applications of laser speckle contrast imaging: a review.Journal of biomedical optics · 2019Review
- Visualization of skin microvascular dysfunction of type 1 diabetic mice using in vivo skin optical clearing method.Journal of biomedical optics · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionMicrovascular changes in the skin due to pharmacological and physiological provocations can be used as a marker for vascular function. While laser Doppler flowmetry (LDF) has been used extensively for measurement of skin microvascular responses, Laser Speckle Contrast Imaging (LSCI) and Tissue Viability Imaging (TiVi) are novel imaging techniques. TiVi measures red blood cell concentration, while LDF and LSCI measure perfusion. Therefore, the aim of this study was to compare responses to provocations in the skin using these different techniques.
methodChanges in skin microcirculation were measured in healthy subjects during (1) iontophoresis of sodium nitroprusside (SNP) and noradrenaline (NA), (2) local heating and (3) post-occlusive reactive hyperemia (PORH) using LDF, LSCI and TiVi.
resultsIontophoresis of SNP increased perfusion (LSCI: baseline 40.9±6.2 PU; 10-min 100±25 PU; p<0.001) and RBC concentration (TiVi: baseline 119±18; 10-min 150±41 AU; p = 0.011). No change in perfusion (LSCI) was observed after iontophoresis of NA (baseline 38.0±4.4 PU; 10-min 38.9±5.0 PU; p = 0.64), while RBC concentration decreased (TiVi: baseline 59.6±11.8 AU; 10-min 54.4±13.3 AU; p = 0.021). Local heating increased perfusion (LDF: baseline 8.8±3.6 PU; max 112±55 PU; p<0.001, LSCI: baseline 50.8±8.0 PU; max 151±22 PU; p<0.001) and RBC concentration (TiVi: baseline 49.2±32.9 AU; max 99.3±28.3 AU; p<0.001). After 5 minutes of forearm occlusion with prior exsanguination, a decrease was seen in perfusion (LDF: p = 0.027; LSCI: p<0.001) and in RBC concentration (p = 0.045). Only LSCI showed a significant decrease in perfusion after 5 minutes of occlusion without prior exsanguination (p<0.001). Coefficients of variation were lower for LSCI and TiVi compared to LDF for most responses.
conclusionLSCI is more sensitive than TiVi for measuring microvascular changes during SNP-induced vasodilatation and forearm occlusion. TiVi is more sensitive to noradrenaline-induced vasoconstriction. LSCI and TiVi show lower inter-subject variability than LDF. These findings are important to consider when choosing measurement techniques for studying skin microvascular responses.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.