ArticleCell host & microbe2015
Posttranslational Modifications of the Master Transcriptional Regulator NPR1 Enable Dynamic but Tight Control of Plant Immune Responses.
Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 101 papers.
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Who cites it
101 citing papers in PubMed, 262 citations in OpenAlex.
- HDA15-Mediated Deacetylation of GPX1 Inhibits Its Nuclear Translocation and Increases Osmotic Stress Sensitivity in Rice.International journal of molecular sciences · 2026Article
- SUMOylation in plants: A versatile post-translational mechanism responding to environmental stresses.Journal of integrative plant biology · 2026Review
- Genome-wide identification and expression analysis of the PnNPR-PnTGA gene family reveal its potential role in response to biotic stresses in Panax notoginseng.BMC plant biology · 2026Article
- Transcriptional outputs and condensates - formation and function.The New phytologist · 2026Review
- Heterologous expression of the barley-specific HvbZIP87 transcription factor in wheat enhances broad-spectrum disease resistance with balanced yield.Journal of advanced research · 2026Article
- Leaf it to science: Uncovering plant immune systems through technological advances.Plant physiology · 2026Review
- Genome-wide identification and expression analysis of the Small Ubiquitin-like Modifier (SUMO) gene family in Triticum aestivum L.BMC genomics · 2025Article
- Rice black-streaked dwarf virus-encoded P6 protein impairs OsPelota-mediated antiviral RNA decay defense via promoting OsSCE1b ubiquitination and degradation in rice.Journal of integrative plant biology · 2025Article
- MdPOB1L Positively Regulates Disease Resistance Against Botryosphaeria dothidea by Manipulating MdNPR1 Protein Stability in Malus domestica.Molecular plant pathology · 2025Article
- Modulation of Plant Interactions with Whitefly and Whitefly-Borne Viruses by Salicylic Acid Signaling Pathway: A Review.Viruses · 2025Review
- ATG6 interacting with NPR1 increaseseLife · 2025Article
- Next-generation mapping of the salicylic acid signaling hub and transcriptional cascade.Molecular plant · 2024Article
- Highly sensitive site-specific SUMOylation proteomics in Arabidopsis.Nature plants · 2024Article
- Genome-wide identification of bZIP transcription factors in 12 Rosaceae species and modeling of novel mechanisms of EjbZIPs response to salt stress.The plant genome · 2024Article
- Article
- INDUCER OF CBF EXPRESSION 1 promotes cold-enhanced immunity by directly activating salicylic acid signaling.The Plant cell · 2024Article
- Heat-induced SUMOylation differentially affects bacterial effectors in plant cells.The Plant cell · 2024Article
- Salicylic acid in plant immunity and beyond.The Plant cell · 2024Review
- Should I stay or should I go? Trafficking of plant extra-nuclear transcription factors.The Plant cell · 2024Review
- Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
- Erratum issued
Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
NPR1, a master regulator of basal and systemic acquired resistance in plants, confers immunity through a transcriptional cascade, which includes transcription activators (e.g., TGA3) and repressors (e.g., WRKY70), leading to the massive induction of antimicrobial genes. How this single protein orchestrates genome-wide transcriptional reprogramming in response to immune stimulus remains a major question. Paradoxically, while NPR1 is essential for defense gene induction, its turnover appears to be required for this function, suggesting that NPR1 activity and degradation are dynamically regulated. Here we show that sumoylation of NPR1 by SUMO3 activates defense gene expression by switching NPR1's association with the WRKY transcription repressors to TGA transcription activators. Sumoylation also triggers NPR1 degradation, rendering the immune induction transient. SUMO modification of NPR1 is inhibited by phosphorylation at Ser55/Ser59, which keeps NPR1 stable and quiescent. Thus, posttranslational modifications enable dynamic but tight and precise control of plant immune responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.