ArticleJournal of therapeutic ultrasound2015
Development of a high-field MR-guided HIFU setup for thermal and mechanical ablation methods in small animals.
Article in Journal of therapeutic ultrasound, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- A Transmit-Receive Phased Array for Microbubble-Mediated Focused Ultrasound Brain Therapy in Small Animals.IEEE transactions on bio-medical engineering · 2025Article
- Histotripsy: A Method for Mechanical Tissue Ablation with Ultrasound.Annual review of biomedical engineering · 2024Review
- Intratumoural immunotherapy plus focal thermal ablation for localized prostate cancer.Nature reviews. Urology · 2024Review
- The histotripsy spectrum: differences and similarities in techniques and instrumentation.International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group · 2023Review
- Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation.Frontiers in immunology · 2022Article
- "HIFU Beam:" A Simulator for Predicting Axially Symmetric Nonlinear Acoustic Fields Generated by Focused Transducers in a Layered Medium.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- A High-Frequency Phased Array System for Transcranial Ultrasound Delivery in Small Animals.IEEE transactions on ultrasonics, ferroelectrics, and frequency control · 2021Article
- Temperature-Responsive Hydrophobic Silica Nanoparticle Ultrasound Contrast Agents Directed by Phospholipid Phase Behavior.ACS applied materials & interfaces · 2019Article
- Ultrasonic sculpting of virtual optical waveguides in tissue.Nature communications · 2019Article
- Cationic gas-filled microbubbles for ultrasound-based nucleic acids delivery.Bioscience reports · 2017Review
- Reconstruction of nonlinear ultrasound field of an annular therapeutic array from acoustic holograms of its individual elements.Proceedings of meetings on acoustics. Acoustical Society of America · 2017Article
- Article
- Evaluation of MR thermometry with proton resonance frequency method at 7T.Quantitative imaging in medicine and surgery · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThermal and mechanical high intensity focused ultrasound (HIFU) ablation techniques are in development for non-invasive treatment of cancer. However, knowledge of in vivo histopathologic and immunologic reactions after HIFU ablation is still limited. This study aims to create a setup for evaluation of different HIFU ablation methods in mouse tumors using high-field magnetic resonance (MR) guidance. An optimized MR-guided-HIFU setup could be used to increase knowledge of the different pathologic and immunologic reactions to different HIFU ablation methods.
methodsThree different HIFU treatment strategies were applied in mouse melanomas (B16): a thermal (continuous wave), a mechanical (5 ms pulsed wave), and an intermediate setting (20 ms pulsed wave) for HIFU ablation, all under MR guidance using a 7 tesla animal MR system. Histopathologic evaluation was performed 3 days after treatment.
resultsThe focus of the ultrasound transducer could accurately be positioned within the tumor under MR image guidance, without substantial damage to the surrounding tissue and skin. All mice retained complete use of the treated leg after treatment. Temperatures of >60, <50, and <44 °C were reached during thermal, intermediate, and mechanical HIFU ablation, respectively. Thermal-treated tumors showed large regions of coagulative necrosis. Tumors of both the mechanical and intermediate groups showed fractionated tissue with islands of necrosis and some pseudocysts with hemorrhage.
conclusionA stable small animal MR-guided HIFU setup was designed and evaluated for follow-up MR imaging and histopathologic responses of the treated tumors. This will facilitate further studies with a larger number of mice for detailed evaluation of the pathologic and immunologic response to different HIFU strategies.
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