ArticleJournal of clinical microbiology2015
Characterization of Foodborne Outbreaks of Salmonella enterica Serovar Enteritidis with Whole-Genome Sequencing Single Nucleotide Polymorphism-Based Analysis for Surveillance and Outbreak Detection.
Article in Journal of clinical microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 77 papers.
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Who cites it
77 citing papers in PubMed.
- Retail wet markets, food handlers, and hospitalised patients as nodes in a shared non-typhoidal Salmonella ecosystem: a one health molecular epidemiological pilot study in Wuhan, China.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2026Article
- Detection ofEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2026Article
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- Traceability analysis of a foodborne disease outbreak caused byFrontiers in public health · 2025Article
- Pathogenic characteristics of an aggregated diarrhea event caused by Plesiomonas shigelloides from stream.PloS one · 2024Article
- Antimicrobial resistance and genomic analysis ofFrontiers in microbiology · 2024Article
- Challenges Associated with InvestigatingFoodborne pathogens and disease · 2023Article
- Genomic Surveillance ofAntibiotics (Basel, Switzerland) · 2023Article
- Prevalence and whole genome phylogenetic analysis reveal genetic relatedness between antibiotic resistance Salmonella in hatchlings and older chickens from farms in Nigeria.Poultry science · 2023Article
- Pan-Genome Analysis of Staphylococcus aureus Reveals Key Factors Influencing Genomic Plasticity.Microbiology spectrum · 2022Article
- Genome-Wide Searching Single Nucleotide-Polymorphisms (SNPs) and SNPs-Targeting a Multiplex Primer for Identification of CommonPathogens (Basel, Switzerland) · 2022Article
- Characterisation ofInternational journal of environmental research and public health · 2022Article
- Development of Single Nucleotide Polymorphism (SNP)-Based Triplex PCR Marker for Serotype-specificPathogens (Basel, Switzerland) · 2022Article
- Whole Genome Multi-Locus Sequence Typing and Genomic Single Nucleotide Polymorphism Analysis for Epidemiological Typing ofFrontiers in microbiology · 2022Article
- Population dynamics and antimicrobial resistance ofFrontiers in microbiology · 2022Article
- Rapid Multilateral and Integrated Public Health Response to a Cross-City Outbreak ofFrontiers in microbiology · 2022Article
- Antimicrobial Susceptibility ofFoods (Basel, Switzerland) · 2021Article
- Whole-Genome Analysis of Multidrug-ResistantPathogens (Basel, Switzerland) · 2021Article
17 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Salmonella enterica serovar Enteritidis is a significant cause of gastrointestinal illness in the United States; however, current molecular subtyping methods lack resolution for this highly clonal serovar. Advances in next-generation sequencing technologies have made it possible to examine whole-genome sequencing (WGS) as a potential molecular subtyping tool for outbreak detection and source trace back. Here, we conducted a retrospective analysis of S. Enteritidis isolates from seven epidemiologically confirmed foodborne outbreaks and sporadic isolates (not epidemiologically linked) to determine the utility of WGS to identify outbreaks. A collection of 55 epidemiologically characterized clinical and environmental S. Enteritidis isolates were sequenced. Single nucleotide polymorphism (SNP)-based cluster analysis of the S. Enteritidis genomes revealed well supported clades, with less than four-SNP pairwise diversity, that were concordant with epidemiologically defined outbreaks. Sporadic isolates were an average of 42.5 SNPs distant from the outbreak clusters. Isolates collected from the same patient over several weeks differed by only two SNPs. Our findings show that WGS provided greater resolution between outbreak, sporadic, and suspect isolates than the current gold standard subtyping method, pulsed-field gel electrophoresis (PFGE). Furthermore, results could be obtained in a time frame suitable for surveillance activities, supporting the use of WGS as an outbreak detection and characterization method for S. Enteritidis.
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