Evidence map›Paper›PMID 26269566›Full record

Trial reportCirculation. Heart failure2015

Supplementation of l-Alanyl-l-Glutamine and Fish Oil Improves Body Composition and Quality of Life in Patients With Chronic Heart Failure.

Christina Wu, Tomoko S Kato, Ruiping Ji, Cynthia Zizola, Danielle L Brunjes, Yue Deng, Hirokazu Akashi, Hilary F Armstrong, Peter J Kennel, Tiffany Thomas and 7 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Circulation. Heart failure, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01534663 (Effects of Glutamine and Fish Oil on Muscle Function in Heart Failure), which is not on this map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01534663 phase2 / phase3completednot on this map

Effects of Glutamine and Fish Oil on Muscle Function in Heart Failure (GlutFish-HF)

TypeinterventionalSponsorColumbia UniversityRan2011 to 2014Enrolled31ConditionsHeart FailureArmsGlutamine and Fish Oil Supplementation, Placebo
3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 37 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Glutamine metabolism in health and disease.Signal transduction and targeted therapy · 2026
    Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Nutrition, dietary recommendations, and supplements for patients with congenital heart disease.International journal of cardiology. Congenital heart disease · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 2 countries.

Christina WuFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Tomoko S KatoFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Ruiping JiFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Cynthia ZizolaFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Danielle L BrunjesFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Yue DengFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Hirokazu AkashiFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Hilary F ArmstrongFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Peter J KennelFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Tiffany ThomasFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Daniel E FormanFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Jennifer HallFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Aalap ChokshiFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Matthew N BartelsFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
Donna ManciniFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
David SeresFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.).
P Christian SchulzeFrom the Division of Cardiology, Department of Medicine (C.W., R.J., C.Z., D.L.B., Y.D., H.F.A., P.J.K., T.T., D.E.F., J.H., A.C., M.N.B., D.M., D.S., P.C.S.) and Division of Cardiothoracic Surgery, Department of Surgery (H.F.A.), Columbia University Medical Center, New York, NY; and Department of Cardiovascular Medicine and Organ Transplantation, National Cerebral and Cardiovascular Center, Osaka, Japan (T.S.K.). pcs2121@cumc.columbia.edu.
United Cerebral Palsy · US

Funding

CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024156 · NCRR · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GINSBERG, HENRY N · 2006 to 2011
$53.0M
Mechanisms of Fatty Acid Uptake By Cardiac MuscleR01HL073029 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI GOLDBERG, IRA J · 2003 to 2021
$6.8M
Cardiac Lipotoxicity and Ceramide Metabolism in Heart FailureR01HL114813 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI COLOMBO, PAOLO C, SCHULZE, P. CHRISTIAN · 2013 to 2017
$3.0M
Metabolism in Heart Failure Translational Research CenterP30HL101272 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI LANDRY, DONALD W · 2009 to 2010
$1.2M
Cardiac and Skeletal Muscle Metabolism and Proteolysis in Heart FailureK23HL095742 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SCHULZE, P. CHRISTIAN · 2009 to 2013
$677k
NCRR NIH HHS UL1 RR024156NHLBI NIH HHS HL073029NHLBI NIH HHS K23 HL095742NHLBI NIH HHS K23 HL095742-01NHLBI NIH HHS P30 HL101272NHLBI NIH HHS P30 HL101272-01NHLBI NIH HHS R01 HL073029NHLBI NIH HHS R01 HL114813
6 · The paper itself

Abstract

backgroundSkeletal muscle dysfunction and exercise intolerance are clinical hallmarks of patients with heart failure. These have been linked to a progressive catabolic state, skeletal muscle inflammation, and impaired oxidative metabolism. Previous studies suggest beneficial effects of ω-3 polyunsaturated fatty acids and glutamine on exercise performance and muscle protein balance. METHODS AND

resultsIn a randomized double-blind, placebo-controlled trial, 31 patients with heart failure were randomized to either l-alanyl-l-glutamine (8 g/d) and polyunsaturated fatty acid (6.5 g/d) or placebo (safflower oil and milk powder) for 3 months. Cardiopulmonary exercise testing, dual-energy x-ray absorptiometry, 6-minute walk test, hand grip strength, functional muscle testing, echocardiography, and quality of life and lateral quadriceps muscle biopsy were performed at baseline and at follow-up. Oxidative capacity and metabolic gene expression were analyzed on muscle biopsies. No differences in muscle function, echocardiography, 6-minute walk test, or hand grip strength and a nonsignificant increase in peak VO2 in the treatment group were found. Lean body mass increased and quality of life improved in the active treatment group. Molecular analysis revealed no differences in muscle fiber composition, fiber cross-sectional area, gene expression of metabolic marker genes (PGC1α, CPT1, PDK4, and GLUT4), and skeletal muscle oxidative capacity.

conclusionsThe combined supplementation of l-alanyl-l-glutamine and polyunsaturated fatty acid did not improve exercise performance or muscle function but increased lean body mass and quality of life in patients with chronic stable heart failure. These findings suggest potentially beneficial effects of high-dose nutritional polyunsaturated fatty acids and amino acid supplementations in patients with chronic stable heart failure. CLINICAL

trial registrationURL: http://www.clinicaltrials.gov. Unique identifier: NCT01534663.

Indexed as

Body CompositionDietary SupplementsQuality of LifeChronic DiseaseDouble-Blind MethodExercise ToleranceFemaleFish OilsGlutamineHand StrengthHeart FailureHumansMaleMiddle AgedMuscle, SkeletalTreatment OutcomeFish OilsGlutamineechocardiographyheart failuremetabolismmuscle, skeletalquality of life

Identifiers

PMID26269566
PMCPMC4802502
OpenAlexW2219731761

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.