Evidence map›Paper›PMID 26269552›Full record

ReviewJournal of neurophysiology2015

Network effects of deep brain stimulation.

Ahmad Alhourani, Michael M McDowell, Michael J Randazzo, Thomas A Wozny, Efstathios D Kondylis, Witold J Lipski, Sarah Beck, Jordan F Karp, Avniel S Ghuman, R Mark Richardson

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed
4.7field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 70 citations in OpenAlex.

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  13. Precision Functional Mapping of the Subcortex and Cerebellum.Current opinion in behavioral sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Ahmad AlhouraniDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Michael M McDowellDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Michael J RandazzoDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Thomas A WoznyDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Efstathios D KondylisDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Witold J LipskiDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Sarah BeckDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania;
Jordan F KarpDepartment of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania; and.
Avniel S GhumanDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania.
R Mark RichardsonDepartment of Neurosurgery, University of Pittsburgh, Pittsburgh, Pennsylvania; Center for the Neural Basis of Cognition, Pittsburgh, Pennsylvania richardsonrm@upmc.edu.
University of Pittsburgh · USCenter for the Neural Basis of Cognition · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The ability to differentially alter specific brain functions via deep brain stimulation (DBS) represents a monumental advance in clinical neuroscience, as well as within medicine as a whole. Despite the efficacy of DBS in the treatment of movement disorders, for which it is often the gold-standard therapy when medical management becomes inadequate, the mechanisms through which DBS in various brain targets produces therapeutic effects is still not well understood. This limited knowledge is a barrier to improving efficacy and reducing side effects in clinical brain stimulation. A field of study related to assessing the network effects of DBS is gradually emerging that promises to reveal aspects of the underlying pathophysiology of various brain disorders and their response to DBS that will be critical to advancing the field. This review summarizes the nascent literature related to network effects of DBS measured by cerebral blood flow and metabolic imaging, functional imaging, and electrophysiology (scalp and intracranial electroencephalography and magnetoencephalography) in order to establish a framework for future studies.

Indexed as

Deep Brain StimulationAnimalsBrainHumansNeural Pathwaysdeep brain stimulationelectrocorticographymagnetoencephalography

Identifiers

PMID26269552
PMCPMC4595613
OpenAlexW1895553207

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.