ArticleGenetics2015
Effects of Interference Between Selected Loci on the Mutation Load, Inbreeding Depression, and Heterosis.
Article in Genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Predictions From Evolutionary Theory for Urban Environments.Evolutionary applications · 2026Article
- Characteristics of duplicated gene expression and DNA methylation regulation in different tissues of allopolyploid Brassica napus.BMC plant biology · 2024Article
- Gametic selection favours polyandry and selfing.PLoS genetics · 2024Article
- Article
- Genetic load and extinction in peripheral populations: the roles of migration, drift and demographic stochasticity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022Article
- Population-level consequences of inheritable somatic mutations and the evolution of mutation rates in plants.Proceedings. Biological sciences · 2021Article
- Partial Selfing Can Reduce Genetic Loads While Maintaining Diversity During Experimental Evolution.G3 (Bethesda, Md.) · 2019Article
- Effect of partial selfing and polygenic selection on establishment in a new habitat.Evolution; international journal of organic evolution · 2019Article
- Rapid functional divergence after small-scale gene duplication in grasses.BMC evolutionary biology · 2019Article
- Slower environmental change hinders adaptation from standing genetic variation.PLoS genetics · 2018Article
- Article
- The Evolutionary Interplay between Adaptation and Self-Fertilization.Trends in genetics : TIG · 2017Review
- Article
- Limits to Adaptation in Partially Selfing Species.Genetics · 2016Article
- Background Selection in Partially Selfing Populations.Genetics · 2016Article
- Lower selfing rates in metallicolous populations than in non-metallicolous populations of the pseudometallophyte Noccaea caerulescens (Brassicaceae) in Southern France.Annals of botany · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A classical prediction from single-locus models is that inbreeding increases the efficiency of selection against partially recessive deleterious alleles (purging), thereby decreasing the mutation load and level of inbreeding depression. However, previous multilocus simulation studies found that increasing the rate of self-fertilization of individuals may not lead to purging and argued that selective interference among loci causes this effect. In this article, I derive simple analytical approximations for the mutation load and inbreeding depression, taking into account the effects of interference between pairs of loci. I consider two classical scenarios of nonrandomly mating populations: a single population undergoing partial selfing and a subdivided population with limited dispersal. In the first case, correlations in homozygosity between loci tend to reduce mean fitness and increase inbreeding depression. These effects are stronger when deleterious alleles are more recessive, but only weakly depend on the strength of selection against deleterious alleles and on recombination rates. In subdivided populations, interference increases inbreeding depression within demes, but decreases heterosis between demes. Comparisons with multilocus, individual-based simulations show that these analytical approximations are accurate as long as the effects of interference stay moderate, but fail for high deleterious mutation rates and low dominance coefficients of deleterious alleles.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.