Evidence map›Paper›PMID 26269493›Full record

Trial reportJournal of geriatric psychiatry and neurology2015

The Association Between Benzodiazepine Use and Depression Outcomes in Older Veterans.

Amanda Leggett, Janet Kavanagh, Kara Zivin, Claire Chiang, Hyungjin M Kim, Helen C Kales

Abstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of geriatric psychiatry and neurology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 19 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Amanda LeggettDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA leggetta@med.umich.edu.
Janet KavanaghDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA.
Kara ZivinDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA Department of Veterans Affairs, Center for Clinical Management Research, Ann Arbor, MI, USA Department of Health Management and Policy, University of Michigan School of Public Health, Ann Arbor, MI, USA Institute for Social Research, University of Michigan, Ann Arbor, MI, USA.
Claire ChiangDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA Department of Veterans Affairs, Center for Clinical Management Research, Ann Arbor, MI, USA.
Hyungjin M KimCenter for Statistical Consultation & Research, University of Michigan, Ann Arbor, MI, USA Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA.
Helen C KalesDepartment of Psychiatry, University of Michigan Medical School, Ann Arbor, MI, USA Department of Veterans Affairs, Center for Clinical Management Research, Ann Arbor, MI, USA.
University of Michigan–Ann Arbor · USVA Center for Clinical Management Research · US

Funding

Training Geriatric Mental Health Services ResearchersT32MH073553 · NIMH · DARTMOUTH-HITCHCOCK CLINIC · PI BRUCE, MARTHA L · 2005 to 2019
$6.4M
Risk of death among veterans with depressionI01HX000475 · VA · VETERANS HEALTH ADMINISTRATION · PI ZIVIN, KARA · 2013 to 2013
–
HSRD VA I01 HX000475NIMH NIH HHS T32 MH073553
6 · The paper itself

Abstract

Benzodiazepines (BZDs) are commonly prescribed to older adults with depression, but it is unknown whether they improve antidepressant (AD) adherence or depressive symptoms. We followed 297 older veterans diagnosed with depression and provided a new AD medication prospectively for 4 months. Data include validated self-report measures and VA pharmacy records. At initial assessment, 20.5% of participants were prescribed a BZD. Those with a BZD prescription at baseline were significantly more likely than those without to have a personality disorder, schizophrenia spectrum disorder, or other anxiety disorder, and higher depressive symptom and anxiety symptom scale scores on average. In adjusted regressions, BZD use was not significantly associated with AD adherence, any improvement in depressive symptoms, or a 50% reduction in depressive symptoms. Our results suggest BZD use concurrent with AD treatment does not significantly improve depressive outcomes in older veterans.

Indexed as

AgedAged, 80 and overAntidepressive AgentsAnxietyAnxiety DisordersBenzodiazepinesDepressionDepressive DisorderDrug MonitoringDrug Therapy, CombinationFemaleHumansMaleMedication AdherenceMiddle AgedPersonality DisordersAntidepressive AgentsBenzodiazepinesadherenceantidepressantsbenzodiazepinesdepressionveterans

Identifiers

PMID26269493
PMCPMC4927262
OpenAlexW2125253746

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.